A cascade Michael/Michael/oxa-Michael reaction between curcumins and isatylidene malononitriles has been developed. Multicyclic spirooxindoles were prepared in excellent yields and diastereoselectivities. DMAP was found to catalyze this transformation efficiently under mild reaction conditions.

The latest IEEE 802.11i uses a keyed hash function, called Michael, as the message integrity code. This paper describes some properties and weaknesses of Michael. We provide a necessary and sufficient condition for finding collisions of Michael. Our observation reveals that the collision status of Michael only depends on the second last block message and the output of the block function in the ...

Based on the existing structure activity relationship for proteasome inhibitors, a number of substituted aryl-2-nitrovinyl derivatives have been synthesized as Michael acceptor and their cytotoxicity and proteasome inhibitory effects were evaluated on two cancer cell lines. Compound 2d exhibited IC50 values of 0.71 and 17.79 μM comparable to bortezomib against MCF-7 and PC-3, respectively. The ...

the one-pot, multi-component synthesis of 4,4′-(arylmethylene)bis(1h-pyrazol-5-ols) by tandem knoevenagel-michael reaction of phenylhydrazine, ethyl acetoacetate and aldehydes in the presence of silica-bonded n-propylpiperazine sulfamic acid (sbppsa) as a recyclable solid acid catalyst was reported. sbppsa showed much the same efficiency when used in consecutive reaction runs.

in the course of the faunistic survey of oribatid mites (acari, oribatida) in shend-abad region of iranian province of east azarbaijan -2008 to 2009- two species of the family quadroppiidae, quadroppia (quadroppia) quadricarinata (michael) and quadroppia (coronoquadroppia) nasalis gordeeva, were collected and identified. both species are newly recorded from iran.