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an efficient synthesis of some novel coumarin derivatives via 1, 4- michael addition of indole to coumarin chalcones catalyzed by cellulose sulphonic acid (csa) under solvent free conditions is described. the corresponding michael addition products were obtained in good to excellent yield. the synthesized compounds were screened for their antibacterial activity against e. coli, s. aureus and an...

the anticoagulant racemic warfarin is synthesized by the michael addition of 4-hydroxycoumarin with benzalacetone in the present of equimolar amounts of imidazolium based ionic liquids [bmim] bf4 and [bmim] br and other reaction solvents such as h2o, pyridine and ammonia in five different tests. also synthesis of a derivative of warfarin (2-methyl-4-phenyl pyrano [3, 2-c] chromen-5(4h)-one) und...

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An efficient synthesis of some novel coumarin derivatives via 1, 4- Michael addition of indole to coumarin chalcones catalyzed by cellulose sulphonic acid (CSA) under solvent free conditions is described. The corresponding Michael addition products were obtained in good to excellent yield. The synthesized compounds were screened for their antibacterial activity against E. coli, S. aureus and an...

An efficient synthesis of some novel coumarin derivatives via 1, 4- Michael addition of indole to coumarin chalcones catalyzed by cellulose sulphonic acid (CSA) under solvent free conditions is described. The corresponding Michael addition products were obtained in good to excellent yield. The synthesized compounds were screened for their antibacterial activity against E. coli, S. aureus and an...

Continuing a line of research opened up by Grigni and Sipser in 4] and further pursued in 10], we show that a wide variety of equivalent characterizations of P still remain equivalent when restricted to be positive. All these restrictions thus deene the same class posP, a proper subclass of monP, the class of monotone problems in P. We also exhibit complete problems for posP under very weak red...

operates in a number of them and earns there only around £30 million. Despite the concerns, many still believe Witty’s pledge marks a major step forward for neglected diseases and developing countries. “He is breaking the mould in validating the concept of patent pools,” said Rohit Malpani at Oxfam’s access to medicines campaign. “It is a big step forward. It is welcome that he is inviting othe...

In the era of the North American Free Trade Agreement (NAFTA), the public and private sectors are increasingly committed to the growth of transport-oriented infrastructure, including ports, highways, bridges, and rail facilities. In particular there has been much interest in international bridges spanning the Rio Grande, the roads and rail lines leading to these bridges, and the port facilities...

RECENTLY there fell into my hands by the kindness of its author a book which has revealed to me a new, and I think much better, understanding of the situation we are facing today in consequence of the modern scientific revolution. The author’s name is Josef Pieper, professor of philosophical anthropology at the University of Münster, and his book which so impressed me is entitled Scizolastik. (...