the present investigation was designed to formulate a natural tablet for the treatment of vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. bioadhesive curcumin vaginal tablets were prepared by direct compression with different ratios of biadhesiv...

Thermoreversible biogels can serve as effective systems for delivery of drugs through nose with increased nasal residence time. The objective of this study was to use chitosan and glycerophosphate based thermoreversible systems for delivery of doxepin to brain through intranasal administration. Formulations were prepared by admixture of suitable dilutions of chitosan and glycerophosphate with o...

Introduction: The buccal mucosa, which contains non-keratinized epithelial cells lining the inner cheeks of the mouth, is a site for local and systemic delivery of medication. This region is highly vascularized and relatively immobile [1]. Buccal delivery allows for the active ingredients to exert rapid onset of action, bypassing liver first pass-metabolism, and avoiding pH fluctuations and deg...

The aim of the present study was to prepare valdecoxib, a cyclo-oxygenase-2 enzyme inhibitor, as a loaded multiparticulate system to achieve site-specific drug delivery to colorectal tumors. Film coating was done with the pH-sensitive polymer Eudragit S100 and sodium alginate was used as mucoadhesive polymer in the core. The microspheres were characterized by X-ray diffraction, differential sca...

BACKGROUND The purpose of this study was to develop a mucoadhesive coacervate microparticulate system to deliver viable Lactobacillus rhamnosus cells into the gut for an extended period of time while maintaining high numbers of viable cells within the formulation throughout its shelf-life and during gastrointestinal transit. METHODS Core coacervate mucoadhesive microparticles of L. rhamnosus ...

The goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body to achieve promptly & then maintain the desired drug concentration. That is why the drug delivery system should deliver dr ug at a state dictated by the needs of the body over a specified period of treatment. This idealized objective points to the two aspects most important to drug del...

Abstract Background The current study expands on the use of design experiment in developing cefuroxime axetil mucoadhesive minitablets for treating antibiotic-associated colitis. A comprehensive QbD-based product development strategy was implemented, with target profile defined based desired quality minitablets. identified critical attributes are profile. goal to find optimum levels by using co...