introduction: the secondary genetic changes other than the pml-rara fusion gene may contribute to the acute promyelocytic leukemogenesis. chromosomal alterations and mutation of flt3 tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia (aml). however, the prognostic significance of flt3 mutations in acute promyelocytic leukemia (apl) is not firmly established....

49,xxxxy is rare chromosomal pattern and these patients have mental retardation, small penis, cryptorchidism and skeletal anomalies. we reported a 10 month-old boy who has hypotonia, microcephaly, hypertelorism, depressed nasal bridge, epicanthic folds and bilateral multiple ear tags, high arched palate, down set ears, micrognathia and congenital heart disease such as patent ductus arteriosus (...

in this study, chromosome analyses were performed on 70 infertile azoospermic and oligospermic (<20 million/ml) men, and also cultures of peripheral blood lymphocytes by high resolution banding method were analysed as well. it is revealed 8 (11.43 percent) men with chromosomal abnormality. there were 31.4 percent patients with azoospermia and 68.6 percent with oligospermia from several thousand...

Already in the late 19th century, the link between chromosomal aberrations and the pathogenesis of cancer was described by von Hanssemann [9]. Moreover, as early as the first decade of the 20th century the German zoologist Theodor Boveri developed a genetic theory of cancer based on these chromosomal aberrations [3]. Until quite recently, these ideas have received only limited attention and foc...

Discussion: A large part of both clinical and subclinical lesions found in our daily work are benign and correspond with fibrocystic changes (FCC). This entity is complex and part exhibit traits that define characteristically in MRI and diagnose correctly, but there is another small group of changes that can take the image aspect of cancer. From a complex case, we review the main aspects of the...

Abstract Using the CRISPR-Cas system, it has been possible to introduce different kinds of mutations in single or multiple genes for trait improvement crops. Last year, first time, CRISPR-Cas-mediated induction targeted heritable chromosomal rearrangements achieved plants. This novel application potential revolutionize plant breeding as genetic exchange and linkage drag are now becoming control...