In 1987, the hobo spider, Tegenaria agrestis, was initially implicated in necrotic lesions in the Pacific Northwest of the United States. This European-origin species has since joined the widow and recluse spiders to become the well-known trio of medically significant spiders in North America. It is currently distributed from British Columbia to Oregon and east to Montana and Colorado, with eas...

OBJECTIVE Accumulation of dying and dead cells is thought to be involved in the etiopathogenesis of systemic lupus erythaematosus (SLE). Clearance has been described mainly for apoptotic cells; however, the knowledge of serum factors participating in the phagocytosis of necrotic cells is limited. PATIENTS AND METHODS Sera from 18 patients with SLE and 10 normal healthy donors (NHD), and macro...

Preservation of viable tissue is important in wound management. It is achieved by small, incremental removal of devitalised, necrotic and infected tissues. Maggot debridement therapy (MDT) is used in septic necrotic wounds that fail to respond to conventional modalities. MDT has relied on Lucilia sericata, which consumes only necrotic tissues, as opposed to Lucilia cuprina, which devours both f...

Compared to other techniques of propagation, grafting is the most successful and feasible technique for asexual propagation of walnut plants. There is little information about graft union formation in walnut. Therefore, the objective of this study was to evaluate histological events during graft union formation in Juglans regia L. cv. Chandler scions when minigrafted on the one-year-old seedlin...

  Introduction: [61Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([61Cu]ATSM) is a well-established hypoxia imaging tracer with simple production and significant specifity. In this work the accumulation of the tracer is studied in wild-type, necrotic and hypoxic fibrosarcoma tumors. Methods: [61Cu]ATSM was prepared u...

Lysosomes and cathepsins, the most common hydrolytic enzymes in lysosomes, are available different models of cell death as necrosis apoptosis. This study investigated effect cathepsin B-selective inhibitor CA-074 on apoptotic necrotic neuronal death. Focal cerebral ischemia which has been formed by occlusion three-vessel consisting permanent middle artery temporary bilateral carotid for 60 minu...

We investigated whether suppression of nitric oxide (NO) implicated in the protective effect of echinacoside (ECH), a phenylethanoid glycoside, on H2O2-induced injury to the rat pheochromocytoma cell line (PC12 cells). Data show that application of ECH to H2O2-injured PC12 cells (HIPCs) increased cell viability and decreased the necrotic ratio. Laser scanning confocal microscopic (LSCM) analysi...

introduction: the aim of this study was to compare the efficacy of two irrigants on decreasing the pain and swelling at different times after treatment of necrotic pulp. materials and methods: fifty patients with single canal tooth and necrotic pulp were selected and divided into two groups, twenty-five in each. rotary files were used for preparing the canals and 0.2% chlorhexidine gluconate an...

Apoptosis and necrosis represent distinct cell death processes that regulate mammalian development, physiology and disease. Apoptosis characteristically leads to the silent destruction and removal of cells in the absence of an inflammatory response. In contrast, necrotic cell death can induce physiologic inflammatory responses linked to tissue defense and repair. Although anucleate, platelets u...