Abstract Biohybrid micro/nanorobots that integrate biological entities with artificial nanomaterials have shown great potential in the field of biotechnology. However, commonly used physical hybridization approaches can lead to blockages and damage interfaces, impeding optimal exploitation natural abilities. Here, we show magnetically propelled plant biobots (MPBs), employing tomato-callus cult...

This study aims to investigate the dynamics characteristics of liquid jet injected from a needle-free injection device by analyzing the the flow visualization from the high-speed video camera and the CFD calculation. This is to investigate the jet flow phenomena (e.g. penetration, dispersion, velocity) in the quiescent air and in the tissue simulant (20% polyacrylamide gel) as the further infor...

The current practice for experimentally evaluating the performance of extraterrestrial rovers/rover wheels is to conduct tests on earth on a soil simulant, appropriate to the regolith on the extraterrestrial body of interest. In the tests, the normal load (force) applied by the rover/rover wheel to the soil simulant is set identical to that expected on the extraterrestrial surface, taking into ...

Dimetyl metylphosphonate (DMMP) is a simulant of sarin, which representative nerve agents. Sarin an organophosphorus toxic compound that inhibitor acetylcholinesterase, paralyzing human neurotransmission and the autonomic nervous system. Detection these agents has been considered important for safety issues to prevent terrorism counter military threats. Although there have various studies on se...

Scopolamine (SCP) is an anticholinergic drug used clinically for decades to treat motion sickness, as a surgical preanesthetic, and as a smooth muscle antispasmodic. It has also been used experimentally as a pretreatment and/or treatment adjunct to mitigate the toxic sequelae of organophosphorus (OP) nerve agent intoxication. SCP has been reported to increase survival, prevent or terminate seiz...

Many chemicals with broad industrial, pharmaceutical and agricultural application produce a neurotoxic syndrome in humans and experimental animals involving weight loss, skeletal muscle weakness and ataxia. Neurotoxicity is defined as a structural change or a functional alteration of the nervous system resulting from exposure to a chemical, biological or physical agent. Neurotoxicity including ...

objective(s) the role of elaeagnus angustifolia fruit as an analgesic agent in acute pain has been proved earlier. in this study, the effects of aqueous extracts of three parts of this fruit (pericarp, medulla and seed) on chronic pain were investigated in mice. materials and methods a partial nerve injury was made using a tight ligature around the sciatic nerve, then doses (0.5, 1, 1.5 g/kg, i...

Organophosphorus nerve agents are the most toxic chemical warfare agents that present a threat to the warfighter. Irreversible inhibition of acetylcholinesterase, by nerve agents leads to accumulation of the neurotransmitter acetylcholine (ACh) at cholinergic synapses (Taylor, 1996). Currently fielded MARK I nerve agent antidote for treatment of nerve agent poisoning protects against life threa...

Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poisoning. Here we impart nerve agent hydrolysis activity into the human drug metabolism enzyme carboxylesterase 1. Using crystal structures of the targe...