Ageing and Neurodegenerative Diseases is an open access multidisciplinary journal, focusing on innovative research advances in the cellular molecular mechanisms underlying ageing process age-related neurodegenerative diseases, such as Alzheimer's disease, Parkinson's amyotrophic lateral sclerosis, etc., therapeutic interventions this field.

Many studies indicate that oxidative stress is involved in the pathophysiology of neurodegenerative diseases. Oxidative stress can induce neuronal damages, modulate intracellular signaling and ultimately leads to neuronal death by apoptosis or necrosis. To review antioxidants preventive effects on oxidative stress and neurodegenerative diseases we accumulated data from internatio...

It has long been believed that the lysosome is an important digestive organelle. There is increasing evidence that the lysosome is also involved in pathogenesis of a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Abnormal protein degradation and deposition induced by lysosomal dysfunction may be...

Zinc (Zn) is abundantly present in the brain, and accumulates in the synaptic vesicles. Synaptic Zn is released with neuronal excitation, and plays essential roles in learning and memory. Increasing evidence suggests that the disruption of Zn homeostasis is involved in various neurodegenerative diseases including Alzheimer's disease, a vascular type of dementia, and prion diseases. Our and othe...

The technology, experimental approaches, and bioinformatics that support proteomic research are evolving rapidly. The application of these new capabilities to the study of neurodegenerative diseases is providing insight into the biochemical pathogenesis of neurodegeneration as well as fueling major efforts in biomarker discovery. Here, we review the fundamentals of commonly used proteomic appro...

Glycogen synthase kinase-3 (GSK-3) regulates multiple cellular processes, and its dysregulation is implicated in the pathogenesis of diverse diseases. In this paper we will focus on the dysfunction of GSK-3 in Alzheimer's disease and Parkinson's disease. Specifically, GSK-3 is known to interact with tau, β-amyloid (Aβ), and α-synuclein, and as such may be crucially involved in both diseases. Aβ...

Quantitative measurement of geometrical and physiological properties of blood vessels in the retina may indicate early stages of brain and systemic diseases in an efficient and cost-effective way. Retinal vasculature is brain vasculature, and can be imaged easily at high resolution with optical fundus or OCT cameras. Breakdown of the blood-brain barrier, as in diabetes, leads to marked vascular...

Citation: Pozo AS. Dietary Nucleotides in Neurodegenerative Diseases. Biochem Mol Biol J. 2016, 1:1. There has been an explosion of scientific interest in the health enhancing role of specific foods or physiologically-active food components, the so-called functional foods [1]. It is believed that diet play an important role against neurodegenerative diseases and some functional foods can help t...

Neurodegenerative diseases are characterized by progressive loss of cognitive function, dementia, and problems with movements. Identification of biomarkers during disease process, induce to an effective and early diagnostic test for neurodegenerative diseases. These biomarkers would allow presymptomatic disease detection of disease and would be valuable for monitoring the efficacy of disease. C...