عطایی, رامین
مرکز تحقیقات علوم دارویی ،دانشگاه علوم پزشکی مازندران-ساری ایران
[ 1 ] - بررسی اثر آنتی پرولیفراتیو و آپوپتوتیک رسوراترول در رده سلولی AGS آدنوکارسینوما معده
Background & Aims: Resveratrol (3,4,5 tri-hydroxy-trans-acetylben-1acetyl benoid) is a phenolic natural product which is found in red grapes also in Japanese knotweed root (polygonum cuspidatum). Resveratrol is also found in Gnetum cleistostachyum. In recent years, many researches were about anti-inflammatory and anti carcinogenic effect of resveratrol especially in breast, colon and...
[ 2 ] - بررسی اثر ضد دیابتی و ضد نوروپاتی رزوراترول و تاثیر آن در بیان ژن Sirt-1 در موش سوری
Background and purpose: Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, impaired insulin secretion or peripheral insulin resistance. Today, many herbal medicines are used in treatment of diabetes. Recently anti-diabetic properties of resveratrol are reported in some studies, but none have evaluated its anti-neuropathy properties and its' effect on Sirt1 gene expression...
[ 3 ] - اثر تجمعی ترانس رزوراترول و ایمی‌پرامین در کاهش نشانه‌های افسردگی موش سوری به روش تست شنای اجباری
زمینه و هدف : رزوراترول ترکیبی گیاهی فنلی با خواص آنتی‌اکسیدانت در بسیاری از بیماری‌ها از جمله سرطان، دیابت و بیماری‌های نورودژنراتیو به عنوان درمان کمکی مطرح شده است. این مطالعه به منظور تعیین اثر تجمعی ترانس رزوراترول و ایمی‌پرامین در کاهش نشانه‌های افسردگی موش سوری به روش تست شنای اجباری انجام شد. روش بررسی : این مطالعه تجربی روی 56 سر موش سفید نر نژاد Swiss Webster انجام شد. حیوانات در 7 گر...
[ 4 ] - بررسی اثرات ضد دیابتی و ضد نوروپاتی عصاره ی هیدروالکلی گل زنگوله ای (Onosma dichroanthum) در مدل تجربی دیابت در موش سوری به وسیله استرپتوزوسین
مقدمه: بیماری دیابت اختلالی متابولیکی است که در آن ترشح انسولین یا حساسیت سلول‌های بدن به انسولین دچار اختلال می‌شود. Onosmaیا گیاه زنگوله‌ای، گونه‌ای از گل گاو زبان در طب سنتی است که به دلیل خواص ضد میکروبی، ضد التهابی و آنتی‌اکسیدانتی مورد استفاده قرار می‌گیرد این مطالعه با هدف بررسی خواص ضد دیابتی و ضد نوروپاتی و اکسیداتیو استرس، در مدل تجربی دیابت در موش سوری طراحی شد. مواد و روش‌ها: پس از...
[ 5 ] - Review Paper: Polyphenolic Antioxidants and Neuronal Regeneration
Many studies indicate that oxidative stress is involved in the pathophysiology of neurodegenerative diseases. Oxidative stress can induce neuronal damages, modulate intracellular signaling and ultimately leads to neuronal death by apoptosis or necrosis. To review antioxidants preventive effects on oxidative stress and neurodegenerative diseases we accumulated data from internatio...
[ 6 ] - Utilization of curcumine and nanocurcumine compounds in cancer therapy
Curcumin is a polyphenol extracted from the Curcuma plant. Curcumin has been used widely in ayurvedic medicine for centuries; it has a variety of biological properties including anti-oxidant, analgesic, anti-inflammatory and antiseptic activity. Curcumin has shown anti-cancer activities through variety of biological pathways engaged in mutagenesis, oncogene expression, cell cycle regulatio...
[ 7 ] - The protective effect of curcumin against lithium-induced nephrotoxicity in rats
Lithium is an element which has been used as salts of chloride or carbonate for many years in the treatment of some psychological disorders such as mania, bipolar or schizophrenic diseases. Chronic application of lithium may induce some serious nephropathies such as natriuresis, renal tubular acidosis, tubulointerstitial nephritis progression to progressive chronic kidney disease and hypercalce...
[ 8 ] - Evaluation of Relationship between Single-nucleotide Polymorphism in TNF-gene Promoter and Susceptibility to Atherosclerosis in Fatemeh Zahra Hospital
Background: Tumor necrosis factor alpha is a proinflammatory cytokine and as polyvalent initial response of inflammatory cells which facilitated through the creation of coronary atherosclerosis . It also seems that the polymorphism and susceptibility to atherosclerosis is related to TNF-α gene promoter. The purpose of this study was to investigate single nucleotide polymorphis...
[ 9 ] - The Serotonin 5-HT2A Receptor Antagonist Ritanserin Induces Apoptosis in Human Colorectal Cancer and Acts in Synergy with Curcumin
Curcumin exhibits both cancer- preventive activity and growth inhibitory effects on several neoplastic cells including human colon cancer. Serotonin and its receptors have also been implicated in tumor development. This study investigated the effect of ritanserin, a selective serotonin 5HT2A receptor antagonist, alone and in combination with curcumin on colorectal cancer cell lines. Result...
[ 10 ] - بررسی اثرات رنوپروتکتیو والپروآت‌سدیم بعنوان مهارکننده هیستون دِاستیلاز در نفروپاتی دیابتی
سابقه و هدف: نفروپاتی دیابتی شایعترین علت بروز مرحله نهایی نارسایی کلیوی، ناشی از فعالیت مولکولهای پیام رسان پروتئین کینازC و گونه های فعال اکسیژن می باشد. مطالعات اخیر به نقش فرآیندهای اپیژنتیک مانند استیلاسیون هیستون و نقش آنزیمهای هیستونداستیلاز و هیستون استیل ترانسفراز در ایجاد این اپیدمی خاموش اشاره کرده اند. والپروآت سدیم بعنوان نوعی مهارکننده هیستون داستیلاز شناخته...
[ 11 ] - بررسی تأثیر متفورمین بر میزان پیشرفت سرطان سلول غیر کوچک ریه توأم با دیابت ملیتوس، مروری بر مطالعات سال های 2015 تا 2017
زمینه و هدف: سرطان سلول غیر کوچک ریه (NSCLC) به عنوان شایع ترین نوع سرطان ریه دارای بیشترین آمار میزان مرگ ناشی از سرطان می باشد. دیابت ملیتوس از شایع ترین کو موربیدیتی های این بیماری بوده و بررسی خاصیت ضد سرطانی متفورمین، به عنوان داروی متداول ضددیابت در بیماران مبتلا به سرطان ریه توأم با دیابت ملیتوس جهت ارائه رژیم درمانی اثربخش تر ضروری به نظر می رسد. هدف از این مطالعه ارائه جدیدترین شواهد...
[ 12 ] - بررسی اثر هم افزایی عصاره هیدروالکلی گیاه زعفران و داروی فلوکستین بر کاهش افسردگی در موش سوری
Introdution:. Over the past several years, therapeutic properties of saffron extract have been proven. Because of antioxidant components of this herb, it has been candidate for some disorders as depression, considering that the effects of saffron on depression and anxiety syndromes are few, the present study aimed to investigate these aspects. Methods: This was an experimental study that 36 Sw...
[ 13 ] - Evaluation of blood sugar lowering effect of airy organs extract of Cupressus sempervirens L. on streptozocin induced diabetic mice
Background and Aim: Cupressus extract has been considered as antioxidant and free radical scavenger. In this study we evaluated the effect of hydroalcoholic extract of Cupressus sempervirens L. on blood sugar, weight and also oxidative stress parameters in experimental diabetic model of mice. Materials and Methods: 48 male mice of albino race were made diabetic with a single dose of streptozoci...
[ 14 ] - Evaluation of the Anti-apoptotic and Anti-cytotoxic Effect of Epicatechin Gallate and Edaravone on SH-SY5Y Neuroblastoma Cells
Introduction: Parkinson disease (PD) is the second most common neurodegenerative disease affecting older individuals with signs of motor disability and cognitive impairment. Epicatechin (EC) and edaravone have neuroprotective effects most probably due to their antioxidant activity; however, a limited number of studies have considered their role in PD. This research aimed at investigating the ne...
[ 15 ] - Antihypoxic Activities of Aerial Parts and Roots of Ferula persica in Mice
Background and purpose: Hypoxia occurs in ischemia and heart attack, and leads to death. It involves production of reactive oxygen species. Antioxidants exhibit antihypoxic properties. Ferula persica has distinctive antioxidant activities. Nothing is known about the protective effect of this plant against hypoxia-induced lethality in mice. Materials and methods: Protective effects of methanol...
[ 16 ] - Association between rs2119882 (MT1A) Melatonin Receptor Polymorphism and Childhood Leukemia Using RFlP-PCR Method
Background and purpose: Melatonin is a well-known neuroendocrine reproductive hormone-based hormone that has an important role in the circadian clock system and has potent antioxidant properties. New studies have also suggested an antitumor role for melatonin. The role of melatonin receptors is proven in many cancers, including colon and breast cancers, but so far, no study has been performed i...
[ 17 ] - Evaluation of Embryonal Protective Effect of Melatonin against Apoptotic Effect of Methadone in Embryo Tissues of Mice
Introduction: Methadone is a substance that is widely used in the substitution treatment of opiate addiction. This study aimed to evaluate the protective effects of melatonin on apoptosis induced by transfer of transplacental methadone in mice. Methods: This study was an experimental study aimed to assay apoptotic effect of placenta transferred methadone on brain, liver and kidney tissues and ...
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