Hossein Asgarian-Omran
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences,Sari, Iran| Immunogenetics Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
[ 1 ] - CD4+ T Cells are Exhausted and Show Functional Defects in Chronic Lymphocytic Leukemia
Background: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. This health problem is caused due to the accumulation of mature B-lymphocytes in the peripheral blood and bone marrow. In the course of cancer, CD4+ T cells become “exhausted” and characterized with poor effector functions and the expression of multiple inhibitory receptors. Objective: To inve...
[ 2 ] - ایمونوفنوتایپینگ بیماران مبتلا به لوسمی لنفوسیتی مزمن (CLL) به روش فلوسیتومتری؛ ارتباط با پیش آگهی بیماری
Background and purpose: Chronic lymphocytic leukemia (CLL) is characterized by clonal proliferation and accumulation of long-lived B lymphocytes within the peripheral blood, bone marrow, and secondary lymphoid organs. In this study, immunophenotypic characteristics of leukemic cells and their association with disease prognosis were investigated in CLL patients. Materials and methods: A case-...
[ 3 ] - Blimp-1 Expression as an Exhaustion Transcription Factor in Chronic Lymphocytic Leukemia
Background: PPreviously, it was shown that exhausted CD4+ and CD8+ T cells in chronic lymphocytic leukemia (CLL) co-express the two immune-inhibitory receptors, Tim-3 and PD-1. Present study investigated the expression of Blimp-1, a transcription factor involved in T cell exhaustion, in patients with CLL. Materials and Methods: Peripheral blood mononuclear cells were collected from 25 untreate...
[ 4 ] - Galectin-9 Expression Profile in Patients with Gastric Cancer and Peptic Ulcer Disease
Background: Chronic inflammation and dys-regulation of the immune system mechanisms are now well established as primary triggers of gastric cancer and peptic ulcer disease. Galectin-9 (Gal-9) is a member of the galectin family and known as an inducer of cell aggregation, adhesion and apoptosis. Gal-9 interaction with its main ligand T-cell immunoglobulin and mucin domain protein-3 (Tim-3) leads...
[ 5 ] - Evaluation of the Anti-apoptotic and Anti-cytotoxic Effect of Epicatechin Gallate and Edaravone on SH-SY5Y Neuroblastoma Cells
Introduction: Parkinson disease (PD) is the second most common neurodegenerative disease affecting older individuals with signs of motor disability and cognitive impairment. Epicatechin (EC) and edaravone have neuroprotective effects most probably due to their antioxidant activity; however, a limited number of studies have considered their role in PD. This research aimed at investigating the ne...
[ 6 ] - Atorvastatin Sensitizes Breast and Lung Cancer Cells to Ionizing Radiation
Tumour cells may be resistant to radiotherapy that results in unsuccessful cancer treatment in patients. The aim of this study was to evaluate the sensitizing effect of atorvastatin (ATV) on breast cancer (MDA-MB-231) and non-small cell lung cancer (A-549) cells following exposure to ionizing radiation (IR). These cells were treated with ATV and exposed to X-ray at dose 4 Gy. The radiosensitizi...
[ 7 ] - Atorvastatin Sensitizes Breast and Lung Cancer Cells to Ionizing Radiation
Tumour cells may be resistant to radiotherapy that results in unsuccessful cancer treatment in patients. The aim of this study was to evaluate the sensitizing effect of atorvastatin (ATV) on breast cancer (MDA-MB-231) and non-small cell lung cancer (A-549) cells following exposure to ionizing radiation (IR). These cells were treated with ATV and exposed to X-ray at dose 4 Gy. The radiosensitizi...
[ 8 ] - Effect of Intralipid Infusion on Pregnancy Outcome in Infertile Women with History of Implantation Failure: A Single Blind Randomized Clinical Trial
Background and purpose: Recurrent implantation failure is one of the problems associated with in vitro fertilization cycles. The aim of this study was to evaluate the results of pregnancy using intralipid infusion in infertile women with history of two implantation failures. Materials and methods: A clinical trial was conducted in 80 infertile women in the infertility center in Sari Imam Khom...
[ 9 ] - Designing an ELISA Method for Measurement of Human IgG and IgM Antibodies against SARS-CoV-2
Background and purpose: Coronavirus disease 2019 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this study, an indirect ELISA method was designed to measure the human IgM and IgG antibodies against SARS-CoV-2. Materials and methods: Protein sequence of nucleocapsid antigen from SARS-CoV-2 was expressed in E. coli BL21 and then was...
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