عجمی, ابوالقاسم

[ 1 ] - مروری بر نقش سلول های مهاری مشتق از رده میلوئیدی در تنظیم سیستم ایمنی

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expands during cancer, inflammation and infection, and together with regulatory T cells (Tregs) have a remarkable ability to suppress immune responses. The phenotype of MDSCs differs in humans and mice, and the exact mechanisms of their suppressive function are still controversially discussed. Limited data are...

[ 2 ] - Production of Cyclin D1 specific siRNAs by double strand processing for gene therapy of esophageal squamous cell carcinoma

Background: RNAi (RNA interference) is a new strategy in gene therapy and biotechnology which provides new promises in the treatment of different diseases such as cancer and viral diseases. CCND1 which is a key gene in cell cycle is amplified and over expressed in esophageal cancer. The objective of this study was production and siRNAs for CCND1, the key gene in cell cycle. Materials and Metho...

[ 3 ] - Prevalence of EPIYA motifs in Helicobacter pylori strains isolated from patients with gastroduodenal disorders in northern Iran

Background: Cytotoxin-associated gene A (CagA)-positive strains of Helicobacter pylori are associated with gastroduodenal diseases. Evidences have suggested that the type of H pylori CagA EPIYA motifs may be associated with specific disorders (i.e., gastritis, peptic ulcer, or gastric cancer).  We investigated the prevalence of different EPIYA motifs (A, B, C, or D) in H. pylori strains is...

[ 4 ] - نقش زیر مجموعه های مونوسیت های خون محیطی در پیشرفت ضایعه آترواسکلروز عروق کرونر

Background and purpose: Circulating monocytes are divided into different subpopulations according to the expression of CD14 and CD16. In this study, we investigated the correlation between the severity of coronary artery disease (CAD) and the frequency of two monocyte subsets and also expression level of CCR1 receptor on these monocytes.   Materials and methods: The study was conducted in 88 p...

[ 5 ] - اثر بربرین بر بیان ژن Bcl-2 در بیماران لوسمی لنفوسیتی مزمن در مقایسه با گروه کنترل

Background and purpose: Anti-apoptotic protein Bcl-2 prevents apoptosis through the mitochondrial pathway and high-level expression of Bcl-2 is required for survival of chronic lymphocytic leukemia (CLL). Berberine (BBR) is an alkaloid that induces apoptosis of cancer cells via mitochondrial pathways. The aim of this study was to investigate the effect of Berberine on Bcl-2 gene expression in p...

[ 6 ] - Over-Expression of Immunosuppressive Molecules, PD-L1 and PD-L2, in Ulcerative Colitis Patients

[ 7 ] - Relationship between Maternal Serum Androgen Levels and Success Rate in ICSI Procedure

Background and purpose: Androgens play a key role in growth of ovarian follicles and female fertility in the process of in vitro fertilization. This study was performed to determine the relationship between androgen levels and success rate in Intracytoplasmic sperm injection (ICSI). Materials and methods: A nested case-control study was carried out in 60 infertile women attending the Infertili...

[ 8 ] - Role of Frizzled receptor expression on patients’ survival with gastrointestinal cancers: A systematic review with meta-analysis

Background: Frizzled receptors (FZD) play a pivotal role in the initiation and progression of a wide array of cancers. Dysregulated expression of FZD receptors is correlated with higher metastasis and invasive potential, as well as short survival in many malignancies. In this meta-analysis, we aimed to verify the prognostic value of FZD receptor expression on patients’ survival with different t...

[ 9 ] - Effect of Intralipid Infusion on Pregnancy Outcome in Infertile Women with History of Implantation Failure: A Single Blind Randomized Clinical Trial

 Background and purpose: Recurrent implantation failure is one of the problems associated with in vitro fertilization cycles. The aim of this study was to evaluate the results of pregnancy using intralipid infusion in infertile women with history of two implantation failures. Materials and methods: A clinical trial was conducted in 80 infertile women in the infertility center in Sari Imam Khom...