• Neuromuscular blocking agents (NMBAs) are often administered during surgical procedures to provide muscle relaxation and prevent patient movement, which may increase the risk of surgical complications • When neuromuscular block no longer needs to be maintained, patients may either be allowed to spontaneously recover neuromuscular function or be administered a reversal agent for more rapid rec...

Incomplete recovery following reversal of neuromuscular blockade can present as a clinical problem in surgical patients. Emerging pharmacologic solutions may prevent such adverse outcomes in the future. We briefly review two methods of pharmacologic reversal of neuromuscular blockade. Both methods of reversal are effective. However the early studies of the new compound, sugammadex has been show...

INTRODUCTION Anesthetic management of patients with Duchenne muscular dystrophy (DMD) is complicated because these patients are more sensitive to nondepolarizing neuromuscular blocking agents (NMBAs) and are vulnerable to postoperative complications, such as postoperative residual curarization and respiratory failure. Sugammadex is a new reversal agent for aminosteroidal NMBAs, but its safety i...

ACQUISITION OF NEUROMUSCUlar dysfunction after admission to the intensive care unit (ICU) has been described during the last decade. Although this condition was first reported in a patient with severe asthma who required high doses of corticosteroids and neuromuscular blocking agents, neuromuscular dysfunction acquired in the ICU has also been frequently reported in patients with sepsis or mult...

l,rAzobis[3-methyl-2-phenyl-lH-imidazo(l,2-a)pyridinium] dibromide, AH 8165, produced a competitive neuromuscular block in the mouse, chick, cat, dog and monkey. The paralysis was characterized by a very rapid onset of action and, in all species except the monkey, by a short duration of action comparable to that of suxamethonium. In the monkey, the effect of AH 8165 was more persistent but was ...

Sugammadex is a revolutionary investigational reversal drug currently undergoing Phase III testing whose introduction into clinical practice may change the face of clinical neuromuscular pharmacology. A modified gamma-cyclodextrin, sugammadex exerts its effect by forming very tight water-soluble complexes at a 1:1 ratio with steroidal neuromuscular blocking drugs (rocuronium > vecuronium >> pan...

The interaction of four inhalational anesthetics (sevoflurane, isoflurane, enflurane and halothane) with pancuronium and vecuronium and also their prejunctional actions at the neuromuscular junction were quantitatively studied using rat phrenic nerve-hemidiaphragm preparations. To investigate the prejunctional effects of inhalational anesthetics, a train-of-four ratio (T4/T1) and the tetanus ra...

effects of venom from black scorpion androctonus crasicuda (ac) were determined on isolated chick biventer cervices nerve-muscle and mouse hemidiaphragm preparations using twitch tension method. the isolated nerves were stimulated by electrical stimulator and response to each stimulus was recorded. the venom mainly acted prejunctionally to facilitate neuromuscular activity due to an increase in...

BACKGROUND This survey aimed to assess the extent of practice of the Middle Eastern anesthesiologists in the use of neuromuscular blocking agents (NMB) in 2012. METHODS We distributed an electronic survey among 577 members of the Triple-M Middle Eastern Yahoo anesthesia group, enquiring about their practice in the use of neuromuscular blocking agents. Questions concerned the routine first cho...