Neuronal plasticity is an important feature of the developing brain and requires neuronal circuits to reconfigure their functional connectivity depending upon activity patterns. To explore changes in neuronal function that occur downstream of altered activity, we performed an expression analysis in Drosophila mutants with acute or chronic alterations in neuronal activity. We find that seizure i...

Spontaneously occurring neuronal oscillations constitute a hallmark of developmental networks. They have been observed in the retina, neocortex, hippocampus, thalamus and spinal cord. In the immature hippocampus the so-called ‘giant depolarizing potentials’ (GDPs) are network-driven membrane oscillations characterized by recurrent membrane depolarization with superimposed fast action potentials...

background: the objective of this study is to develop a new animal model based on signaling pathways to understand the pathophysiology, therapy of depression, and to investigate the antidepressant activity of enicostemma littorale which is not yet established. methods: animal models of depression were raised by physical methods and administration of methyl isobutyl ketone (100 mg/kg b.w., i.p.,...

Neuronal activity produces transient ionic currents that may be detectable using magnetic resonance imaging (MRI). We examined the feasibility of MRI-based detection of neuronal currents using computer simulations based on the laminar cortex model (LCM). Instead of simulating the activity of single neurons, we decomposed neuronal activity to action potentials (AP) and postsynaptic potentials (P...

Background: Epilepsy is characterized by a persistent predisposition of the brain to generate epileptic seizures, due abnormal neuronal activity reflected as involuntary muscle movement. This disturbance may lead important hospital admissions, which differ in prevalence based on distinct age groups.

Since its first experimental signatures, the so called “critical brain hypothesis” has been extensively studied. Yet, actual foundations remain elusive. According to a widely accepted teleological reasoning, would be poised critical state optimize mapping of noisy and ever changing real-world inputs, thus suggesting that primary sensory cortical areas should critical. We investigated whether si...

Spontaneously occurring neuronal oscillations constitute a hallmark of developmental networks. They have been observed in the retina, neocortex, hippocampus, thalamus and spinal cord. In the immature hippocampus the so-called ‘giant depolarizing potentials’ (GDPs) are network-driven membrane oscillations characterized by recurrent membrane depolarization with superimposed fast action potentials...