OBJECTIVE Nitric oxide is produced by endothelial nitric oxide synthase, and its production can be influenced by polymorphisms of the endothelial nitric oxide synthase gene. Because candidate genes responsible for susceptibility to ankylosing spondylitis are mostly unknown and available data suggest that there may be problems related to the nitric oxide pathway, such as endothelial dysfunction ...

ACTH = adrenocorticotrophic hormone; ARDS = acute respiratory distress syndrome; CO = cardiac output; CT = computed tomography; CVP = central venous pressure; CVVHF = continuous venovenous haemofiltration; eNOS = endothelial nitric oxide synthase; ICU = intensive care unit; LPS = lipopolysaccharide; NO = nitric oxide; PAWP = pulmonary artery wedge pressure; PEEP = positive end-expiratory pressu...

BACKGROUND Recent evidence suggests that nitric oxide produced via the neuronal nitric oxide synthase is involved mainly in the early response to sepsis, whereas nitric oxide derived from the inducible nitric oxide synthase is responsible during the later phase. We hypothesized that early neuronal and delayed inducible nitric oxide synthase blockade attenuates multiple organ dysfunctions during...

Nitric oxide is produced by almost all cardiac cells, endothelial cells, cardiomyocytes and nerve fibers. It is synthesized by an enzyme, a nitric oxide synthase, which occurs in endothelial, neural and inducible form. The distribution of nitric oxide synthase in the heart is characterized by a pronounced non-uniformity. Nitric oxide exerts its effects in physiological and pathophysiological co...

BACKGROUND Inducible or neuronal nitric oxide synthase gene deletion increases or decreases anxiety-like behavior in mice, respectively. Since nitric oxide and endocannabinoids interact to modulate defensive behavior, the former effect could involve a compensatory increase in basal brain nitric oxide synthase activity and/or changes in the endocannabinoid system. Thus, we investigated the expre...

BACKGROUND AND PURPOSE Endothelial nitric oxide synthase produces superoxide under physiological conditions leading to hydrogen peroxide (H(2)O(2)) -dependent dilations to acetylcholine in isolated mouse cerebral arteries. The purpose of this study was to investigate whether H(2)O(2) was involved in flow-mediated dilation (FMD). METHODS Cerebral arteries were isolated from 12+/-2-week-old C57...

in this study, we aimed to investigate the peripheral antinociception effects of specificphosphodiesterase 5 (pde-5) inhibitor vardenafil on carrageenan-induced nociception in rats,and the role of calcium besides the l-arginine- nitric oxide (no)- cyclic guanosine monophophate(cgmp) pathway in these effects. hyperalgesia was induced by the intraplantar injection of 0.1ml fresh carrageenan solut...

Correspondence: Roberto Lozano Ortiz Pharmacy Department, Hospital Real Nuestra Señora de Gracia, Zaragoza, Ramon y Cajal 6050004 Zaragoza, Spain Tel +3 49 7644 4300 Fax +3 48 7676 4555 Email [email protected] Having read with great interest the article by Goto et al and in order to clarify further some of the results presented in this article, especially with regard to the action of atyp...

Nitric oxide is a short-lived reactive mediator that inhibits bone marrow (BM) cell proliferation induced by granulocyte-macrophage colony-stimulating factor (GM-CSF). The present studies show that nitric oxide also inhibits macrophage colony-stimulating factor (M-CSF)-induced growth of mouse BM cells, an effect that was dependent on the presence of an inflammatory mediator and blocked by the n...