Çiğ sütün içerdiği mikroorganizma çeşitliliği ve bunların direnç profili potansiyel olarak insan sağlığı gıda endüstrisi için bir tehlike arz etmektedir. Bu çalışmada sağlıklı hayvanlardan elde edilen süt örneklerinin patojen ihtivası yönünden incelenmesi, yaygın kontaminantı Streptococcus spp. prevalansının antibiyotik profillerinin araştırılması amaçlanmıştır. 249 örneğinden Staphylococcus sp...

Nitrofurans (furazolidone, furaltadone, nitrofurantoin, nitrofurazone) belong to a wide range of synthetic antibiotics used in the prevention gastrointestinal infections livestock, aquaculture and beekeeping. They were also as food supplements stimulate growth. In 1995, use nitrofurans veterinary medicine was banned European Union because carcinogenic potentially harmful effects humans. Illegal...

Human African trypanosomiasis (HAT), caused by the protozoan parasite Trypanosoma brucei spp., is a major health problem in sub-Saharan Africa. New drugs are urgently required for the disease. Selective uptake of toxic compounds into trypanosomes has been achieved by exploiting plasma membrane transporters. For example, the P2 aminopurine transporter, along with other transporters, selectively ...

Our studies showed that various nitrofuran derivatives have excellent radiosensitizing properties in hypoxic Chinese hamster cells at concentrations at which there is no effect on plating efficiency. The radiosensitizing effect is primarily a dose-modifying effect, with nitrofurantoin, nitrofurazone, and nifuroxime (each at 500 ¿M) in complete medium giving enhancement ratios of 1.65, 2.0, and...

When Escherichia coli strain B/r is exposed to 10 to 20 mug of nitrofurazone per ml, mutants with roughly threefold resistance are obtained. Treatment of these mutants with higher concentrations of nitrofurazone yields strains with six- to seven-fold resistance over strain B/r. Each of these steps toward nitrofurazone resistance is accompanied by loss of soluble nitrofurazone reductase activity...

The nitrofuran antimicrobial agent, furazolidone (FZ), is still used in veterinary medicine in some countries in the Middle and Far Eastern countries. The present study aimed to investigate the effects of successive bolus doses of FZ and its metabolite 3-amino-2-oxazolidinone (AOZ) on cytochrome P450 (CYP)-related activities in the livers of rats and chickens. Female Wistar rats and white Legho...