A high omega-6/omega-3 ratio, as is found in today's Western diets, promotes the pathogenesis of many chronic diseases, including cardiovascular disease. Increased dietary intake of linoleic acid (LA) leads to oxidation of low-density lipoprotein (LDL), platelet aggregation, and interferes with the incorporation of essential fatty acids (EFA) in cell membrane phopholipids. Both omega-6 and omeg...

Peptide channel blockers found in venoms of many predators are useful pharmacological tools and potential therapeutic agents. The venom of the Brazilian spider Phoneutria nigriventer contains a fraction, omega-phonetoxin-IIA (omega-Ptx-IIA, 8360 MW), which blocks Ca2+ channels. At frog neuromuscular junctions (NMJ) bathed in normal Ca2+ (1.8 mM) saline, omega-Ptx IIA did not affect spontaneous ...

BACKGROUND Physical exercise and healthy dietary habits are recommended to prevent breast cancer. DISCUSSION Increased intake of omega-3 fatty acids associated with decreased omega-6 - resulting in higher omega-3 to omega-6 ratio compared with Western-type diet - is inversely associated with breast cancer risk. The modernized Mediterranean diet with high omega-3 to omega-6 ratio, high fiber a...

The possible backbone phosphodiester conformations in a dinucleoside monophosphate and a dinucleoside triphosphate have been investigated by semiempirical energy calculations. Conformational energies have been computed as a function of the rotations omega' and omega about the internucleotide P-O(3') and P-O(5') linkages, with the nucleotide residues themselves assumed to be in one of the prefer...

We have reexamined the hydroxylation of [1-14C]-lauric acid by trout liver microsomes and reconstituted trout P450s using a new HPLC system that gave an improved separation of hydroxylauric acids. Under these conditions, hepatic microsomes from yearling juvenile trout were shown to form omega-, (omega-1)-, (omega-2)-, (omega-3)-, (omega-4)-, (omega-5)-, and (omega-6)-OH lauric acid oxidation pr...

In the OMEGA study on patients after myocardial infarction, 1 the anticipated statistical power of 80% was not reached, which was attributed to the low incidence of sudden cardiac death in patients receiving current guideline-adjusted medical treatment. To detect an improvement of clinical outcome by omega-3 fatty acids, it is considered important to focus on patients with poor heart function. ...

We investigate structures that can be represented by omega-automata, so called omega-automatic structures, and prove that relations defined over such structures in first-order logic expanded by the first-order quantifiers ‘there exist at most א0 many’, ’there exist finitely many’ and ’there exist k modulo m many’ are omega-regular. The proof identifies certain algebraic properties of omega-semi...

We study band dispersion relations omega(k-->) of a photonic crystal with at least one of the constitutive components being a magnetically ordered material. It is shown that by proper spatial arrangement of magnetic and dielectric components one can construct a magnetic photonic crystal with strong spectral asymmetry (nonreciprocity) omega(k-->) not equal omega(-k-->). The spectral asymmetry, i...

Several sources of information suggest that human beings evolved on a diet with a ratio of omega-6 to omega-3 essential fatty acids (EFA) of approximately 1 whereas in Western diets the ratio is 15/1-16.7/1. Western diets are deficient in omega-3 fatty acids, and have excessive amounts of omega-6 fatty acids compared with the diet on which human beings evolved and their genetic patterns were es...