BACKGROUND While many factors have been examined, male gender and older age at multiple sclerosis onset are among few variables consistently associated with increased disability. Interestingly, the association between onset age and disability may not be linear with some data suggesting a faster rate of accumulation of disability in patients aged more than 30 years at onset. OBJECTIVE Explore ...

BACKGROUND Clinical outcome of Chinese relapsing remitting multiple sclerosis (RRMS) patients is uncertain. AIM To study the long-term clinical outcome of Chinese RRMS patients. METHOD RRMS patients with duration of 10 years or longer followed up in our hospital is retrospectively studied. RESULTS 61 RRMS patients (75% female) were studied. Their mean symptom onset age was 25.9 years and ...

sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system. There evidence to support link between herpesvirus infections and an associated increased risk of developing MS. Over past two years, neurological complications with COVID-19 infection have been reported are speculated be caused by direct viral invasion. A relatively low connection MS development has identif...

Despite frequent muscle strength or muscle oxidative capacity (based on exercise-onset oxygen uptake [VO2] kinetics) assessments in patients with multiple sclerosis, the impact of time of day on these parameters is often not taken into account. Based on observations in healthy subjects, it remains to be studied whether muscle strength, and/or exercise-onset VO2 kinetics, varies between the morn...

OBJECTIVE To study the prevalence and the natural course of transitional progressive multiple sclerosis (TPMS). This clinical form is defined by a progressive course beginning many years after an isolated bout. METHODS 214 consecutive outpatients with definite or probable multiple sclerosis were studied. The prevalence of TPMS was established. Patients with TPMS were compared with patients wi...