Overproduction of microbial metabolites is related to developmental phases of microorganisms. Inducers, effectors, inhibitors and various signal molecules play a role in different types of overproduction. Biosynthesis of enzymes catalysing metabolic reactions in microbial cells is controlled by well-known positive and negative mechanisms, e.g. induction, nutritional regulation (carbon or nitrog...

background: nitric oxide (no), a major chemical form of endothelium-derived relaxing factor and an important regulator of vascular tone, is released by endothelial cells. the role of no is not restricted to the vascular system, and it participates in the regulation of renal hemodynamics and renal excretory function. there are increasing evidences indicating that the elevated levels of no play a...