The cholesterol oxidase-catalyzed oxidation of cholesterol in native low density (LDL) and high density lipoproteins (HDL3) as well as in monolayers prepared from surface lipids of these particles, has been examined. The objective of the study was to compare the oxidizability of cholesterol, and to examine the effects of lipid packing on oxidation rates. When [3H]cholesterol-labeled lipoprotein...

It has been shown (3) in a previous paper (1928) that plants which contain a peroxidase syst,em and the suprarenal cortex of animals contain a relatively high concentration of a substance called hexuronic acid. This substance is characterized by its high reducing power and its reversible oxidizability. It has been suggested that hexuronic acid is involved as a catalyst in the resphation of the ...

BACKGROUND/AIM In patients with end-stage renal disease (ESRD), cardiovascular complications are the main cause of death. Increased oxidative stress is one of the risk factors for enhanced atherosclerosis in this population. Literature data vary partially dependent on differences in methodology. The present study compares three different methods: plasma lipid peroxides, the newly developed meas...

OBJECTIVE Coronary artery diseases including myocardial ischemia (MI) remain one of the leading causes of death worldwide. This study was designed to compare the protective effect of L-arginine versus aspirin from the biochemical changes associated with MI injury. EXPERIMENTAL DESIGN Four groups of male New Zealand white rabbits were investigated. Normal group (n = 8) rabbits were fed standar...

Low density lipoproteins (LDL) were modified in vitro in the presence of lipid transfer activity and lipolysis, which induced alterations in the size and lipid composition of LDL particles but not in their antioxidant content. Subsequently, modified LDL were oxidized with copper sulfate and the extent of LDL oxidation was evaluated. Lipid transfer activity alone, or in combination with lipolysi...

Background: A great deal of evidence has indicated that oxidatively modified LDL plays a critical role in the initiation and progression of atherosclerosis. Antioxidants that can prevent LDL oxidation may act as antiatherogens. Copper is a candidate for oxidizing LDL in atherosclerotic lesions. The binding of copper ions to LDL is usually thought to be a prerequisite for LDL oxidation by copper...

Catechins in green tea have been shown to reduce a risk of coronary heart disease in epidemiological studies. Also, it has been reported catechins have hypolipidemic and antioxidant effects. Then, we investigated the effects of ground green tea drinking on the susceptibility of plasma and low-density lipoprotein (LDL) to the oxidation by CuSO4 ex vivo, and also evaluated daily food consumption ...