objective(s):drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. analgesics such as nsaids have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. meloxicam is one of nsaids with no topical form in the market. in this research, we attempted to quantify the skin permeation of a m...

ASTM A 182 F22 steel, used in components subsea for oil extraction, are previously buttered with ductile metal such as Inconel 625, before being welded to steel pipes similar A36 steels. The thermal buttering weld cycle provides the formation of high hardness micro-phases and carbides at interface between Inconel, which when contact hydrogen, originating from cathodic protection applied these e...

The Kv2.1 potassium channel contains a lysine in the outer vestibule (position 356) that markedly reduces open channel sensitivity to changes in external [K(+)]. To investigate the mechanism underlying this effect, we examined the influence of this outer vestibule lysine on three measures of K(+) and Na(+) permeation. Permeability ratio measurements, measurements of the lowest [K(+)] required f...

While post-grouting is frequently reported to improve the engineering performance of piles, shear strength soil around piles not well understood. To investigate strengthening mechanism with permeation grouting, laboratory tests were carried out on homemade cement from aspects and microstructure characteristics. The evolution rule stress–shear displacement curve grouting different contents was a...