Multiple Sclerosis (MS) is a complex disease resulting from the occurrence of intermingled episodes of neuro-inflammation and degeneration. The temporal and spatial patterns in which these events occur are not well understood as well as the molecular substrates underlying it. Myelin loss and gain, as well as axonal damage are considered crucial events influencing the course of the disease but t...

background & aim: pain is the main stressful factor in patients hospitalized in intensive care units(icu). non-pharmacological methods for pain relief are preferred by icu patients due to lack of considerable side effects. the present research aims to determine the effect of tens on pain intensity followed by surgery in patients hospitalized in intensive care units. setting of the study was bes...

background and objective: genus salacia l. (celastraceae) is a woody climbing medicinal plant consisting of about 200 species with many endangered species located throughout the world’s tropical areas. various parts of the plant as food, functional food additive and tea have been extensively used to treat a variety of ailments like diabetes and obesity as well as inflammatory and skin diseases....

background: androgen receptors (ar) play an important role in proliferation of cancerous prostatic cells and prevention of apoptotic signaling. current drugs cannot inhibit the activity of these receptors very well. establishment of appropriate animal models is essential for discovery of new drugs of target therapy in hormone dependent prostate cancer. materials and methods: standard prostatic ...

alcohol provokes different molecular pathways contributing to a clinically significant neurotoxicity in different brain areas. affected cognition in alcoholics can influence both daily life functioning and alcohol craving management abilities. preventing alcohol-induced neurotoxicity with different neuroprotective pharmacological interventions is receiving strong scientific backgrounds from pub...

Treatment developments, brain imaging studies, and results of pharmacological research elicit revision related pathological theories to Obsessive-compulsive disorder (OCD) new patterns. One the important alluring patterns under neurobiological approach corresponding pathology treatment obsessive-compulsive is animal models which are used in this disorder. Insomuch, many endeavors have been appl...

conclusions both add-on ldt and switching to peg-ifn-α2a were satisfactory and optimal treatments for chb patients with poor responses to adv. both rescue strategies resulted in significant reductions in serum viral load and alt levels, and were associated with high rate of serological outcomes in our hospital. patients and methods ninety-seven chb patients with hbv dna > 2 log10 copies/ml 48 w...

oxidative stress (os), which has been implicated in pathogenesis of many acute and chronic diseases, plays an important role in diverse neurological disorders including depression and anxiety. os is caused by a large amount of reactive oxygen species or impaired enzymatic or non-enzymatic defense against it. os has been suggested to contribute to etiology of mentioned disorders. this review int...