نتایج جستجو برای: pi3kakt pathway

تعداد نتایج: 313376  

Guang-yu Liu Jin-ming Yu, Li Yan, Wei-hong Gong Wen-jun Chen Yan-xia Zhang

Objective(s): The Janus kinase-signal transducers and activators of transcription signaling pathway (JAK/STAT pathway) play an important role in proliferation of breast cancer cells. Previous data showed that inhibition of STAT3 suppresses the growth of breast cancer cells, but the associated mechanisms are not well understood. This study aims to investigate the effect and associated mechanisms...

Objective(s): To investigate and test the hypotheses that TGF-β1 enhanced myocardial differentiation through Wnt/β-catenin pathway with rat bone marrow mesenchymal stem cells (BMSCs).Materials and Methods: Lentiviral vectors carrying the TGF-β1 gene were transduced into rat BMSCs firstly. Then several kinds of experimental methods were u...

ژورنال: کومش 2020

Introduction: The incidence rate of liver cancer is continuously increasing. Currently, gene therapy is applied to improve various medical issues such as cancer treatment approaches. Correspondingly, fibromodulin involves in many biological and physiological processes through interaction with growth factors and signaling pathway receptors. The aim of this study was to investigate the effects of...

ژورنال: رویش روانشناسی 2021

The aim of this study was to investigate the relationship between early maladaptive schemas and antisocial and borderline personality disorder mediated by morbid hostility and negative emotion. This research is a descriptive and path analysis that a statistical sample of 359 people (230 females and 129 males), which was available in the range of 18 to 50 years old in the city of Mashhad was sel...

Background & Aims: Triple-negative breast cancer cells refer to any breast cancer that does not express the genes for the estrogen, progesterone, and HER2 receptors. The Wnt signaling pathway is important in the development and progression of various types of cancers. Quinacrine, a derivative of 9-aminoacridine, has been shown to inhibit the growth of several types of cancer cells. In this stud...

Objective(s): Recent studies revealed that microRNAs (miRNAs) may play crucial roles in the responses and pathologic processes of spinal cord injury (SCI). This study aimed to investigate the effect and the molecular basis of miR-103 on LPS-induced injuries in PC12 cells in vitro and SCI rats in vivo. Materials and Methods: PC12 cells were exposed to LPS to induce cell injuries to mimic the in ...

اندرسون, یوران, بنککام, اریک, جمات, نوید, رحیمی میانجی, قدرت, نجفی, مجتبی, هومبلت, پاتریس, گئو, یونچه,

Lipopolysaccharide is a component of outer membrane of gram-negative bacteria involved in the pathogenic process leading to mastitis and metritis in dairy cattle. Additionally, LPS could be caused endometrium inflammation and implantation failure in many animal species. Based on economic importance of these diseases in dairy cattle industry, analysis of differential gene expression (DGE) and al...

Objective(s): The aim of this study was to investigate the effect of curcumin on the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) and its underlying potential mechanism.Materials and Methods: The tissue explant adherence method was used to isolate hPDLSCs. Flowcytometry, Alizarin Red staining and Oil Red ...

Journal: :Standards in Genomic Sciences 2011

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