Solar ultraviolet (UV) irradiation leads to distinct changes in the skin connective tissues by degradation of collagen, which is a major structural component in the extracellular matrix. UV irradiation induces the production of matrix metalloproteinases (MMP) capable of attacking native fibrillar collagen and responsible for inhibiting the construction of collagenous extracellular matrix. In th...

This study aimed to illustrate the dose-response relationships of direct scavenging activity amide-based local anesthetics against multiple free radicals in vitro. We have demonstrated that amide-type selectively and directly scavenge some radicals. Three kinds were eliminated by all four examined. Mepivacaine, lidocaine, bupivacaine, dibucaine scavenged hydroxyl dose-dependent manners. Ascorby...

Linguistic adaptation is a process by which interlocutors adjust their production to their environment. In the context of humancomputer interaction, past research showed that adult speakers adapt to computer speech in various manners but less is known about younger age groups. We report the results of three priming experiments in which children in different age groups interacted with a prerecor...

Rutaecarpine (RUT), the major bioactive ingredient isolated from the Chinese herb Evodia rutaecarpa, possesses a wide spectrum of biological activities, including anti-inflammation and preventing cardiovascular diseases. However, its high cytotoxicity hampers pharmaceutical development. We designed and synthesized a derivative of RUT, bromo-dimethoxyrutaecarpine (Br-RUT), which showed no cytoto...