Intestinal stem cells (ISCs) are a group of rare cells located in the intestinal crypts which are responsible for the maintenance of the intestinal homeostasis and intestinal regeneration following injury or inflammation. Lineage tracing experiments in mice have proven that ISCs can repopulate the entire intestinal crypt. It is noteworthy that in such experiments, only a subset of intestinal cr...

Background: Regarding the strong differentiation and anti-leukemic activity of Dendrostellera lessertii extract, an active agent with similar capabilities was isolated from the crude extract of the plant leaves. The aim of this study was to determine whether the anti-proliferative effect observed for this compound, is differentiation-dependent among the drug-treated cells, using U937 cells. Me...

Protein-bound polysaccharide-K (PSK) is extracted from Coriolus versicolor (CM101), and is clinically used in combination therapy for gastrointestinal cancer and small cell lung carcinoma. PSK is a biological response modifier (BRM), and its mechanism of action is partly mediated, by modulating host immune systems, such as the activation of immune effector cells and the neutralization of transf...

BACKGROUND In previous papers we demonstrated that the activity of short heteroretinoids as anti-proliferative and pro-apoptotic compounds was deeply linked to their heterocyclic moiety and that ionone-derived 1,5-pyrazoles had the highest anti-proliferative activity in our preliminary experiments. We then demonstrated the high and pharmacologically significant anti-proliferative and apoptotic ...

BACKGROUND Melicope ptelefolia is a well-known herb in a number of Asian countries. It is often used as vegetable salad and traditional medicine to address various ailments. However, not many studies have been currently done to evaluate the medicinal benefits of M. ptelefolia (MP). The present study reports antioxidant, anti-proliferative, and apoptosis induction activities of MP leaf extracts....

A growth stimulating activity has been recently identified in the rat proximal intestine during the transient stages of adaptation after small bowel resection. This study shows that the growth stimulating activity is associated with all the cells of the crypt-villus axis. At the same time the thymidine kinase activity is detectable in all the cells implying a more extensive proliferative zone d...

objective: this study was performed to determine whether melatonin at physiological concentrations (0.01-10nm) could affect the proliferation and osteogenic differentiation of rat adscs in vitro. materials and methods: adscs were isolated from the fat of adult rats. after cell expansion in culture media and through three passages, osteogenesis was induced on a monolayer culture with osteogenic ...