the pre.sent rep.or,t describes the morphological and if nod h pron erative aspects of lymph es iii odgkin s disease grown in tissue culture. the development of hodgkin's lymph-nodes grown in vitro seems to depend upon the  a~e of t~e person and the stage of the hodgkin's disease at the time the i h is obtained. ymp - the morphological and the proliferative aspects ('helralcterizi~d of hodgkin'...

Rosai-Dorfman disease (RDD) is a rare benign histiocytic proliferative disorder predominantly of the lymph nodes, which mostly occurs in children and young adults typically presenting with lymphadenopathy. Our case is of a 63 year-old African-American male who presented with subjective fever, weight loss, bilateral axillary and inguinal lymphadenopathy as well as auto-immune hemolytic anemia. T...

Pigmented villonodular synovitis (PVNS) is a benign proliferative disorder primarily occurring in the large joints of the appendicular skeleton such as the knee and hip joints. We present an unusual case of PVNS involving the cervical spine in an adult. MR imaging showed an enhancing mass lesion arising from the posterior elements of the cervical spine and hyperintensity on the T2-weighted imag...

Endothelium is a dynamic organ which lines the entire vascular system. Endothelial cells control vascular function by responding to various hormones, neurotransmitters and vasoactive factors which affect vasomotion, thrombosis, platelet aggregation and inflammation. These functions are compromised in endothelial dysfunction, a systemic disorder that is characterized by a proinflammatory, prolif...

Juvenile xanthogranuloma is a relatively uncommon, benign histiocytic proliferative disorder. A case of juvenile xanthogranuloma in a 13-month-old girl with an unusual clinical form is described. She presented with a yellow-red projecting nodule over the helical rim of her right ear. The lesion was histologically diagnosed as juvenile xanthogranuloma after excisional biopsy. Although primarily ...

Castleman’s disease is a rare lympho proliferative disorder with unclear pathogenesis. It is found in two forms, localized (uni-centric) and multi-centric. Histologically there are two forms; hyaline vascular and plasma cell type. The disease is definitely diagnosed by histological examination after biopsy. Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Gallium 67 scintigraphy can ...

This case report is concerned with a 30 year old patient diagnosed with pigmented villonodular synovitis (PVNS) in the knee. The patient underwent an orthopedic surgical operation to remove the lesions. PVNS is a rare proliferative disorder, mostly benign and affecting the knee; its aetiology remains unclear. It represents a medical challenge because of non-specific symptoms that delay the diag...

Rosai-Dorfman disease is a rare histiocytic proliferative disorder of unknown etiology typically characterized by cervical lymphadenopathy. Extranodal involvement often manifests in the head and neck region. We present a 10-year-old male who presented to our hospital with left epiphora from an aggressive paranasal mass invading the left orbit with osseous destruction. The mass was surgically bi...

Background Dupuytren’s disease (DD) is a debilitating fibro-proliferative disorder of the hand characterized by the appearance of fibrotic lesions (nodules and cords) leading to flexion contractures of the fingers and loss of hand function. Although the molecular mechanism of DD is unknown, it has been suggested that transforming growth factorβ2 (TGF-β2) may play an important role in the underl...

Oral administration of 13-cis-retinoic acid (40 or 160 milligrams per kilogram of body weight daily) significantly reduced the inflammation associated with developing and established adjuvant arthritis, an experimentally induced arthritis in rats that resembles human rheumatoid arthritis. The amount of collagenase secreted in tissue culture by adherent cells isolated from the inflamed joints of...