BACKGROUND Propranolol, as a beta-adrenergic blocker is used for treatment of a large number of cardiovascular diseases such as hypertension and arrhythmias. The inhibitory effects of propranolol on tumor cells growth and also its cytotoxicity on cancerous cells have been revealed by several studies. In this study the sensitivity of a number of human leukemic cell lines to propranolol was evalu...

Twelve patients with paroxysmal supraventricular tachycardia (PSVT) were studied before and after administration of 0.1 mg/kg i.v. propranolol. Echo zones for inducing atrioventricular (A-V) nodal reentry were determined using His bundle recording and the atrial extrastimulus technique. After propranolol the echo zone was abolished in two patients, decreased in one, unchanged in five, increased...

Abstract Background Oncolytic viruses (OVs) are considered a promising therapeutic alternative for cancer. However, OVs could activate the host innate immunity, then impair viral propagation in tumor cells. In this study, we explored effect of propranolol, non-selective β-blocker, on antitumor efficacy T1012G virus gastric cancer models. Methods The proliferation cells treated with monotherapy ...

the β2-adrenergic effects of macerated extract, aqueous extract, ethanol extract, and essential oil of carum copticum, 5 nm propranolol, and saline were tested by performing cumulative log concentration-response curves of isoprenaline-induced relaxation of precontracted isolated guinea pig tracheal chains in three different conditions including: non-incubated (group 1, n=9) incubated with 1 µm ...

Background: Akathisia is a common adverse effect of antipsychotic drugs and is characterized by subjective feelings of restlessness. First-line treatment usually consists of propranolol, a beta adrenergic antagonist. However, propranolol does not seem to be efficacious in up to 70% of patients. This study was aimed to evaluate the effect of vitamin B6 versus propranolol on antipsychotic-induced...

nolol is essentially complete, and no metabolism of this drug occurs in the gut. After the oral administration of propranolol, the liver is the principal site of extensive pre-systemic and systemic metabolism, and less than 1% of the intact drug is found in the urine. However, Bianchetti et al. showed that the area under the concentration–time curve for orally administered propranolol in renal ...

a one-pot synthesis of (s)-(-)-propranolol is reported. zn(no3)2/(+)-tartaric acid catalyzed enantioselective synthesis of (s)-(-)-propranolol via kinetic resolution of key intermediate ?-naphthyl glycidyl ether with high optical and chemical yield.

background hemangiomas, usually, present at the first few hemangiomas, usually, present at the first few months of life and are the most common benign tumor in children. there are various therapeutic methods for hemangioma. capillary hemangioma is a type of hemangiomas. the steps of treatment of a child with capillary hemangioma in taleghani hospital of gorgan, iran, are reported. case report i...

Krag, Aleksander, Lene Simonsen, Jens H. Henriksen, Lone Ottesen, and Flemming Bendtsen. Effect of meal and propranolol on whole body and splanchnic oxygen consumption in patients with cirrhosis. Am J Physiol Gastrointest Liver Physiol 291: G8–G15, 2006. First published February 23, 2006; doi:10.1152/ajpgi.00315.2005.—Our aim was to measure whole body energy expenditure after a mixed liquid mea...

OBJECTIVES/HYPOTHESIS Propranolol has recently been introduced as a novel pharmacologic treatment for infantile hemangiomas. Systematic examination of this treatment in a tertiary care setting has not been described. This study explores the impact of propranolol on both proliferative and involuting hemangiomas at a tertiary vascular anomalies center. STUDY DESIGN Retrospective single institut...