A catalytic enantioselective synthesis of (+)-eucomic acid is reported. A palladium-catalyzed asymmetric allylic alkylation is employed to access the chiral tetrasubstituted α-hydroxyacid moiety found in the natural product. The protecting group strategy was investigated, and a protecting group manipulation was made without any appreciable deleterious effects in the allylic alkylation reaction....

Novel photolabile protecting groups based on the 2-(2-nitrophenyl)propoxycarbonyl (NPPOC) group with a covalently linked thioxanthone as an intramolecular triplet sensitizer exhibit significantly enhanced light sensitivity under continuous illumination. Herein we present a detailed study of the photokinetics and photoproducts of nucleosides caged with these new protecting groups. Relative to th...

The 5'-alkynylation of uridine-derived aldehydes is described. The addition of alkynyl Grignard reagents on the carbonyl group is significantly influenced by the 2',3'-di-O-protecting groups (R1): O-alkyl groups led to modest diastereoselectivities (65:35) in favor of the 5'R-isomer, whereas O-silyl groups promoted higher diastereoselectivities (up to 99:1) in favor of the 5'S-isomer. A study r...

We present an experiment addressed to verify the validity of the entanglement quantifier R, defined as the ratio between single counts and coincidence distribution width for pure biphoton states generated by short pump pulses. We demonstrate that this ratio can be efficient to estimate entanglement degree in frequency domain. Our work has been performed with a femto second pulsed laser pump add...

An effective-medium approach is used to derive a set of coupled-mode equations describing quadratic parametric interactions in a one-dimensional inhomogeneous medium of finite length. The solutions for both copropagating and counterpropagating interactions are used to study the quantum-mechanical process of spontaneous parametric down-conversion (SPDC). An example is studied in which the inhomo...