Development of molecular markers that help to identify high-risk individuals or diagnose indeterminate pulmonary nodules could have a major impact on lung cancer clinical management. In this study, we evaluated the diagnostic potential of a newly-developed ELISA that specifically detects complement C4d. We measured this marker in five independent cohorts of plasma and bronchoalveolar lavage sam...

Lung Pulmonary nodules are commonly observed in patients with cancer as well as in patients with no known malignancy particularly in heavy smokers. Most of these nodules are small (less than 8 mm). Even in cancer patients a large proportion of these small nodules are benign [1]. The likelihood of malignancy depends on individual aspects (cancer type, grading, staging, molecular markers etc.), n...

A 50-year-old white man was admitted to the hospital for evaluation of abnormal findings on chest film. Three weeks prior to admission, he developed left pleuritic chest pain associated with some mild cough. No fever was noted at that time. Radiologic evaluation disclosed multiple, bilateral pulmonary nodules, some of which were suspected to be cavitary in nature. The patient had a seven-year h...

PURPOSE To prospectively assess the accuracy of combined wash-in and washout characteristics at dynamic contrast material-enhanced multi-detector row computed tomography (CT) in distinguishing benign from malignant solitary pulmonary nodules. MATERIALS AND METHODS Institutional review board approval and informed consent were obtained. The study included 107 patients (62 men, 45 women; mean ag...

Minute pulmonary meningothelial-like nodules (PMNs) are asymptomatic, small nodules that are occasionally detected in surgical or autopsy specimens. Recent improvements in tumor imaging and the increased use of computed tomography (CT) scans of the chest have led to the early detection of these pulmonary nodules in various clinical settings, often before surgery or health examinations. However,...

BACKGROUND The minimal invasive investigation of solitary pulmonary nodules becomes increasingly important with the emergence of lung cancer screening. OBJECTIVES We report the results of the first utilization of a recently developed procedure in a bronchoscopy suite, which approaches solitary pulmonary nodules via a transparenchymal path. METHODS This study was a prospective, single-arm in...

OBJECTIVE We wanted to evaluate the usefulness of the computer-aided detection (CAD) system for detecting pulmonary nodules in real clinical practice by using the CT images. MATERIALS AND METHODS Our Institutional Review Board approved our retrospective study with a waiver of informed consent. This study included 166 CT examinations that were performed for the evaluation of pulmonary metastas...

tuberculos gumma is one of the various clinical manifestations of cutaneous tb that is characterized by non tender, undolent subcutaneous nodules which progressively involve the skin and take the appearance of an ulcer. in this article, we present two young patients, affected with tuberculos gumma. one of them, presented with multiple abcesses on the face and extremities, associated with pulmon...

Pulmonary hyalinising granulomas are rare, noninfectious fibrosclerosing lesions of the lung which can mimic metastatic disease. It was first described in literature by Engleman et al in the year 1977. Its etiology is unknown but they may be caused by an exaggerated immune response. The patient typically presents with cough, chest pain. dyspnoea or haemoptysis in association with multiple bilat...