In this study, a variety of original ligands related to Combretastatin A-4 and isoCombretastatin A-4, able inhibit the tubulin polymerization into microtubules, was designed, synthesized, evaluated. Our lead compound 15d having quinazoline as A-ring 2-substituted indole B-ring separated by N-methyl linker displayed remarkable sub-nanomolar level cytotoxicity (IC50 < 1 nM) against 9 human cancer...

The title compound, C9H8N2O, is almost planar, with the C atom of the meth-oxy group deviating from the mean plane of the quinazoline ring system (r.m.s. deviation = 0.011 Å) by 0.068 (4) Å. In the crystal, mol-ecules form π-π stacks parallel to the b-axis direction [centroid-centroid separation = 3.5140 (18) Å], leading to a herringbone packing arrangement.

CuO nanoparticles were found to be efficient catalysts for the synthesis of quinazoline derivatives; twenty-four products were obtained with good to excellent yields via reaction of N-arylamidines and aromatic aldehydes or benzyl alcohol in air. Neither a base nor an organic oxidant was necessary, and CuO nanoparticles can be recycled without a significant decrease in catalytic activity.

In the title compound, C(8)H(5)ClN(2)O, the quinazoline system is approximately planar with a maximum deviation from the least-squares plane of 0.034 (2) Å. In the crystal, classical N-H⋯O and weak non-classical C-H⋯N hydrogen bonds link the mol-ecules.

A simple strategy for the synthesis of the hitherto unreported 3-arylazo-4-phenyl-[1,2,4]triazepino[2,3-H]quinazoline-2,7(1H)-diones is described. Spectral data indicated that the studied compounds exist predominantly in the hydrazone tautomeric form. The antimicrobial activity of the newly synthesized compounds was also evaluated. The results indicated that some of these compounds have moderat...

In two double-blind, randomized cross-over comparison studies undertaken in elderly subjects, a new quinazoline derivative, prazosin, has been shown to be a safe and effective antihypertensive agent to which there is a progressive response over four- to six-week periods of oral administration at fixed dose-levels.

The heterocyclic compounds are very important part of medicinal chemistry, among them it is worth to pay attention on derivatives of quinazoline. They have a broad spectrum of pharmacological activities like anticancer (1ñ3), anti-HIV (3), antitubercular (4), anti-inflammatory (5), anticonvulsant (6) and antihypertensive activity (7). The most recognized derivatives among quinazolines with anti...