Human cells contain four homologous Ras proteins, but it is unknown whether these homologues have different biological functions. As a first step in determining if Ras homologues might participate in distinct signaling cascades, we assessed whether a given Ras guanine nucleotide exchange factor could selectively activate a single Ras homologue in vivo. We found that Ras-GRF/Cdc25Mm activates Ha...

We show that, in relativistic field theories, the thermal correlation function of N bosonic operators at sufficiently spacelike-separated points shows exponentially weak dependence on time variables t_1,...,t_N, when space separations are held fixed. For classical theory, vanishes all spacelike separated

The purpose of this study was to investigate 1) the effect of feet distance on static postural balance and 2) the location of natural feet distance and its possible role in the relationship of feet distance and postural balance. Static balance tests were performed on a force platform for 100 s with six different feet distances (0, 5, 10, 15, 20, 25 cm). Measures of postural balance included mea...

Let $T_1, T_2$ be regular trees of degrees $d_1, d_2 \geq 3$. also $\Gamma \leq \mathrm{Aut}(T_1) \times \mathrm{Aut}(T_2)$ a group acting freely and transitively on $VT_1 VT_2$. For $i=1$ $2$, assume that the local action $\Gamma$ $T_i$ is $2$-transitive; if moreover $d_i 7$, contains $\mathrm{Alt}(d_i)$. We show irreducible, unless $(d_1, d_2)$ belongs to an explicit small set exceptional val...

Conditionally specified Gaussian Markov random field (GMRF) models with adjacency-based neighbourhood weight matrix, commonly known as neighbourhood-based GMRF models, have been the mainstream approach to spatial smoothing in Bayesian disease mapping. In the present paper, we propose a conditionally specified Gaussian random field (GRF) model with a similarity-based non-spatial weight matrix to...

Gene-regulation functions (GRF) provide a unique characteristic of a cis-regulatory module (CRM), relating the concentrations of transcription factors (input) to the promoter activities (output). The challenge is to predict GRFs from the sequence. Here we systematically consider the lysogeny-lysis CRMs of different temperate bacteriophages such as the Lactobacillus casei phage A2, Escherichia c...

This study investigated how changes in the material properties of a landing mat could minimise ground reaction forces (GRF) and internal loading on a gymnast during landing. A multi-layer model of a gymnastics competition landing mat and a subject-specific seven link wobbling mass model of a gymnast were developed to address this aim. Landing mat properties (stiffness and damping) were optimise...

The importance of the measurement of human locomotion for the processes of diagnosis and treatment of locomotion disorders is increasingly being recognized. Human locomotion, in particular walking and running are defined by sequences of cyclic gestures. The variability of these sequences can reveal abilities or motorskill failures. The purpose of this study is to analyze and to characterize a r...

The purpose of this study was to (1) determine whether symmetry in temporal-distance (T-D) measures is accompanied by symmetry in kinetic measures during self-paced gait and (2) evaluate the effect of symmetry on gait speed in individuals with chronic stroke. A symmetry index was calculated for stance time, swing time, step length and vertical ground reaction force (GRF) for 28 individuals with...