Rectal cancer: ESMO Clinical Recommendations for diagnosis, treatment and follow-up B. Glimelius & J. Oliveira On behalf of the ESMO Guidelines Working Group* Department of Oncology, Radiology and Clinical Immunology, University Hospital, Uppsala and Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden; Service of Medical Oncology, Portuguese Institute of Oncology, Lisb...

Evidence-based guidelines are important tools and common pathways for translating evidence into clinical practice. It is most urgently needed when significant heterogeneity in practice exist. Actively engaging opinion leaders in the process of evidence-based guidelines development is important for several reasons. These include allowing the collective views of the practice communities to be rep...

Bile acids are increasingly discussed in the genesis of colorectal carcinoma. In a pilot study we analysed bile acids in tumor tissue, tumor-free mucosa, serum, and feces o £ 6 patients with recta1 and 5 patients with colonic carcinoma, 5 patients dead from nongastroenterological diseases and two operated on for benign colonic stenosis seryed as controis for celorecta1 mucosa, 16 healthy person...

The history of rectal cancer management informs current therapy and points us in the direction of future improvements. Multidisciplinary team management of rectal cancer will move us to personalized treatment for individuals with rectal cancer in all stages.