OBJECTIVE To examine psychosocial predictors of successful pregnancy after recurrent spontaneous abortions (RSA). METHOD We administered two waves of semi-structured interview and self-report questionnaire battery to a consecutive series of 46 couples who had had two RSAs (baseline before third pregnancy, and immediately after third pregnancy was ascertained), and followed them through their ...

We investigated the expression of methyl transferase G9a and methylated histone H3-K9 in fresh human decidual/endometrial tissue of 12 normal early pregnancies and 15 unexplained recurrent spontaneous abortions (URSA). The samples were obtained through dilatation and curettage and collected as per strict inclusion-exclusion criteria. The tissue was subjected to immunohistochemical analysis (IHC...

To the Editor : Cranioectodermal dysplasia-1 (CED1), also known as Sensenbrenner syndrome (MIM 218330), is characterized by skeletal, craniofacial, and ectodermal abnormalities (1). Here, we report a family with CED1 and recurrent abortions. I-2 , 39-year-old woman, was referred to our hospital for consultation regarding recurrent abortions. Although she had one healthy boy (II-2), she suffered...

Couples with multiple miscarriages are at risk for carrying a balanced translocation since they may produce unbalanced gametes. Chromosomal imbalances may lead to spontaneous abortions, or an offspring with multiple congenital anomalies. This report emphasizes the importance of the cytogenetic investigations in couples with recurrent spontaneous abortions. A couple was referred for cytogenetic ...

Spontaneous abortion (SAb) is the most common complication of early pregnancy. Numerous risk factors are associated with an increased risk of pregnancy loss such as: Blighted ovum. The aim of this study was to determine the frequency of balanced chromosomal translocations in couples with a history of recurrent spontaneous abortions and ultrasound diagnosed blighted ovum. Sixty Eight couples wit...

Recurrent miscarriage is an important problem in reproductive health, which affects 1-5% of couples. The aim of this article is to summarize current knowledge on the genetic causes of recurrent miscarriage. It presents the most common parental genetic disorders (karyotype abnormalities, recessive diseases carrier status, dominant diseases and thrombophilia) connected with recurrent pregnancy lo...

background: recurrent abortion is a difficult medical problem happening in about 1-2% of fertile women. most spontaneous miscarriages which happen in the first and second trimesters are caused by chromosomal abnormalities. objective: the present study tries to find the rate of chromosomal abnormalities in couples with recurrent pregnancy loss. materials and methods: in total 165 couples were re...

Background: Recurrent pregnancy loss (RPL) is a multifactorial problem associated with genetic abnormalities reflected by inherited disorders. The aim of the present study was to investigate the contribution of heterochromatin polymorphism in couples with recurrent miscarriages compared with couples without miscarriages. Materials and Methods: Over a 3 year period, we made a study of the diagno...