Background -Recurrent pregnancy loss defined as two or more miscarriage before 20 weeks of pregnancy affecting 1-5 % or women in reproductive age .There are many etiologies have been suggested, like Genetic, Immunologic, Thrombophila, Endocrine and Anatomic; but in 50% of cases, the exact etiology remains uncertain. Endometrium acts as biosensor of embryo quality and endometrium itself contribu...

This review focuses on the possible role of T cells in successful pregnancy and in unexplained recurrent abortion. The functions exhibited by Th1 and Th2 cells have suggested, perhaps in a simplistic way, that Th1-type cytokines, which promote allograft rejection, may compromise pregnancy, whereas the Th2-type cytokines, by inhibiting Th1 responses, promote allograft tolerance and therefore may...

Some case-control studies have demonstrated that caffeine intake and high CYP1A2 activity increase risks of recurrent pregnancy loss (RPL) but the multifactorial effect is obscure. To investigate whether susceptible women who have more caffeine intake are at high risk of RPL, a case-control study of 58 cases with two or more RPL and fertile 147 controls was performed. The association between da...

AIM The aim of this study was to determine plasma Growth Arrest Specific Protein 6 (GAS6) protein levels in patients with unexplained recurrent pregnancy loss (RPL) and compare them to those of pregnant and to healthy non-pregnant women with a history of at least one live delivery. PATIENTS AND METHODS A total of 205 women were included in the study. Of these, 68 were diagnosed with unexplain...

Background Effects of GCSF (Granulocyte Colony-stimulating Factor) injection in patients suffering from recurrent pregnancy loss has been studied in some studies and we now know that transvaginal perfusion of G-CSF might be helpful for improvement of implantation rate among patients with thin endometrium and patients under in vitro fertilization /embryo transfer (IVF/ET) or intracytoplasmic spe...

Aim and Objective: Investigating for pregnancy loss is usually recommended only after two or more losses. But women with single seek explanation, in practice. This study conducted order to determine the identifiable causes their proportion early compare that of recurrent (RPL). Materials Methods: cross-sectional analytical undertaken between January 2021 2022. Group A included 50 B RPL. The inv...

BACKGROUND Recurrent pregnancy loss (RPL) is defined as two or more consecutive pregnancy losses before twenty weeks of gestation. It is caused by a variety of genetics and non-genetics factors. Thyroid autoimmunity could associate with pregnancy loss. OBJECTIVE To investigate the effectiveness of Levothyroxine in treatment of RPL in women with high auto-thyroid antibodies. MATERIALS AND ME...

Background/Aims: Chronic endometritis (CE) is a poorly investigated pathology that has been related to adverse reproductive outcomes, such as implantation failure and recurrent miscarriage. In this paper we aim to provide an overview about diagnosis, etiology, pathophysiology and treatment of CE, its impact on endometrial microenvironment and how it may be associated with infertility. Methods: ...

OBJECTIVE To assess the effectiveness of luteal start vaginal micronized P in a recurrent pregnancy loss (RPL) cohort. DESIGN Observational cohort study using prospectively collected data. SETTING Not applicable. PATIENT(S) Women seen between 2004 and 2012 with a history of two or more unexplained pregnancy losses <10 weeks in size; endometrial biopsy (EB) performed 9-11 days after LH sur...