The present study aimed at exploring the potential of the P-glycoprotein (P-gp) transporters as a barrier to the repaglinide (REG) epithelial permeability. In-vitro intestinal absorption models, the everted gut sac, and Caco-2 cell line, were used to study the possible role of P-gp in intestinal transport of REG. In the everted gut sacs, apparent permeability coefficients showed cargo concentra...

The (.)reg construction was introduced in order to make an arbitrary semigroup S divide a regular semigroup (S)reg which shares some important properties with S (e.g., finiteness, subgroups, torsion bounds, J-order structure). We show that (S)reg can be described by a rather simple complete string rewrite system, as a consequence of which we obtain a new proof of the normal form theorem for (S)...

author team: Michel d. landry Pt, Phd; Mandy McGlynn BSc Pt, MSc; edith ng ot reg. (ont); angie andreoli BSc (Pt), MSc; tess devji ot reg. (ont); Cheryl Bower Mn rn(eC); anita Goyal, ot reg. (ont); Sylvia Haycock ot reg. (ont); Jamie a. Young Pt; diane leber rn, etn, BScn; Kristina Guy Pt, BSc(HK), BScPt, MSc(c); anita Vanderwerf rn; Jackie Wright rn, BScn; Suzanne iafolla MPt; ian M. Horne rn,...

The impact of regulatory T cells (T reg cells) on the course of HIV and SIV disease is unknown. T reg cells could suppress protective antiviral responses and accelerate disease progression. Alternatively, these cells might block T cell activation and thereby limit viral replication as well as activation-associated immunopathology. Given the higher frequency of T reg cells known to be present du...

Regenerating (REG) proteins are associated with islet development, β-cell damage, diabetes and pancreatitis. Particularly, REG-1 and REG-3-beta are involved in cell growth/survival and/or inflammation and the Reg1 promoter contains interleukin-6 (IL-6)-responsive elements. We showed by transcriptome analysis that islets of Goto-Kakizaki (GK) rats, a model of spontaneous type 2 diabetes, overexp...

The T-regulatory (T-reg) cells restrict the T-cell functions in various viral infections including influenza infection. However little is known about the effect of T-regs in influenza vaccination. Herein, we found that immunization of BALB/c mice with a prototype of UV-inactivated influenza PR8/A/34 virus vaccine expanded the CD4(+)Foxp3(+) T-reg pool and fostered the development of virus-speci...

Foxp3(+) CD4 regulatory T cells (T reg cells) are important in limiting immunopathology in infections. However, identifying pathogen-specific epitopes targeted by these cells has been elusive. Using MHC class II/peptide tetramers and intracellular cytokine staining, we identify T reg cells recognizing two virus-specific CD4 T cell epitopes in the coronavirus-infected central nervous system as w...

Early studies examining the effect of Regulation Fair Disclosure (Reg FD) report a possible chilling effect on the quantity and quality of corporate disclosures. Approved in August 2000 by the Securities and Exchange Commission (SEC), Reg FD mandates against selective disclosure of corporate information. At the time of its release, the financial community expressed concern that the regulation w...

Mutations in the gene encoding the transcription factor Foxp3 lead to fatal autoimmune pathology in mice and humans, which is associated with a deficiency in Foxp3(+) regulatory T cells (T(reg)). It has also been proposed that Foxp3 inactivation in nonhematopoietic tissues, particularly in thymic epithelium, is required for the pathogenesis, because Foxp3 mutant scurfy bone marrow cells fail to...