The thick ascending limb occupies a central anatomic and functional position in human renal physiology, with critical roles in the defense of the extracellular fluid volume, the urinary concentrating mechanism, calcium and magnesium homeostasis, bicarbonate and ammonium homeostasis, and urinary protein composition. The last decade has witnessed tremendous progress in the understanding of the mo...

Tissue perfusion allows for delivery of oxygen and nutrients to tissues, and in the kidneys is also a key determinant of glomerular filtration. Quantification of regional renal perfusion provides a potential window into renal (patho) physiology. However, non-invasive, practical, and robust methods to measure renal perfusion remain elusive, particularly in the clinic. Arterial spin labeling (ASL...

Kazuhiro Nakaya, Donald G. Harbidge, Philine Wangemann, Bruce D. Schultz, Eric D. Green, Susan M. Wall, and Daniel C. Marcus Cellular Biophysics Laboratory, Cell Physiology Laboratory, and Epithelial Cell Biology Laboratory, Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas; Department of Otolaryngology-Head and Neck Surgery, Tohoku University Graduate School of M...

1Department of Physiology and Biophysics, Center for Excellence in Cardiovascular-Renal Research, The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA 2Department of Cardiology, Center for Medical Education and Career Development, Fukushima Medical University, 1 Hikarigaoka, Fukushima, Fukushima City 960-1295, Japan 3Department of Clinical and Experiment...

Intra-abdominal hypertension (IAH) associated with organ dysfunction defines the abdominal compartment syndrome (ACS). Elevated intra-abdominal pressure (IAP) adversely impacts pulmonary, cardiovascular, renal, splanchnic, musculoskeletal/integumentary, and central nervous system physiology. The combination of IAH and disordered physiology results in a clinical syndrome with significant morbidi...

The thick ascending limb occupies a central anatomic and functional position in human renal physiology, with critical roles in the defense of the extracellular fluid volume, the urinary concentrating mechanism, calcium and magnesium homeostasis, bicarbonate and ammonium homeostasis, and urinary protein composition. The last decade haswitnessed tremendous progress in the understanding of themole...

By virtue of its unique interactions with kidney cells, lithium became an important research tool in renal physiology and pathophysiology. Investigators have uncovered the intricate relationships of lithium with the vasopressin and aldosterone systems, and the membrane channels or transporters regulated by them. While doing so, their work has also led to 1) questioning the role of adenylyl cycl...

New methods in molecular biology and genetics have made possible many of the dramatic advances in physiological research that have occurred in recent years. For those of us who spend most of our time in the research laboratory, it si sometimes difficult to avoid a research-oriented, reductionist mind-set when discussing physiology with students. This article illustrates, with a few examples, th...

during the recent decades, substantial changes are made in the borders and contents of physiology as a basic course for the students in medicine. here some strategies are presented to preserve the classical and integrative approaches in teaching physiology, while these approaches extent our knowledge to molecular, sub-cellular and cellular levels.