نتایج جستجو برای: rhob

تعداد نتایج: 449  

تجزیه و تحلیل خوشه‌ای داده‌های پتروفیزیکی به عنوان روشی خودکار و سریع برای تعیین گروه‌های سنگی موجود در مخازن ماسه‌سنگی به کار می رود و از این رو در مطالعات تعیین کیفیت مخازن به عنوان یک روش کاربردی مورد استفاده قرار می‌گیرد. انتخاب نگار‌های مناسب با توجه به نوع محیط مورد مطالعه، اهمیت ویژه‌ای در فرآیند خوشه‌بندی، تعیین سنگ‌شناسی و نتیجه‌گیری در مورد کیفیت مخزن می‌یابد. در این پژوهش به منظور شن...

2016
Mercedes Piedad de León-Bautista Maria Del Carmen Cardenas-Aguayo Diana Casique-Aguirre Manuel Almaraz-Salinas Sara Parraguirre-Martinez Angelica Olivo-Diaz María Del Rocío Thompson-Bonilla Miguel Vargas

RhoGDI proteins have been implicated in several human cancers; changes in their expression levels have shown pro- or anti-tumorigenic effects. Pancreatic Ductal Adenocarcinoma (PDAC) is a complex pathology, with poor prognosis, and most patients die shortly after diagnosis. Efforts have been focused on understanding the role of RhoGDI's in PDAC, specially, RhoGDI1 and RhoGDI2. However, the role...

2015
Adnan Arshad Eric Deutsch Marie-Catherine Vozenin

Stroma mediated wound healing signals may share similarities with the ones produced by tumor's microenvironment and their modulation may impact tumor response to the various anti-cancer treatments including radiation therapy. Therefore we conducted this study, to assess the crosstalk between stromal and carcinoma cells in response to radiotherapy by genetic modulation of the stroma and irradiat...

2012
Hui-Chi Tsai David L. Boucher Anthony Martinez Clifford G. Tepper Hsing-Jien Kung

Recent studies identifying putative truncated androgen receptor isoforms with ligand-independent activity have shed new light on the acquisition of androgen depletion independent (ADI) growth of prostate cancer. In this study, we present a model system in which a C-terminally truncated variant of androgen receptor (TC-AR) is inducibly expressed in LNCaP, an androgen-dependent cell line, which e...

2012
Christina M. Sloan Clancy V. Quinn Justin P. Peters Janean Farley Chris Goetzinger Molly Wernli Kris A. DeMali Shawn M. Ellerbroek

RhoA, RhoB and RhoC GTPases are over 85% identical at the amino acid level, with RhoA and RhoC differing at only one residue (43) across the initial two-thirds of their sequences. A putative regulatory distinction between the molecules is their capacity to be uniquely activated by guanine nucleotide exchange factors (GEFs). We hypothesize that variation of amino acid residue 43 between RhoA/B (...

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