In osteoblasts only the type III Na(+)-dependent phosphate (NaPi) transporter isoforms Pit-1 and Pit-2 have been identified. We tested the effects of extracellular Pi, Ca(2+) and IGF-I on Na(d)Pi transport and Pit-1 or Pit-2 mRNA expression in rat osteoblastic (PyMS) cells. The v(max) of Na(d)Pi transport was higher in cells kept in Pi-free, serum-free medium for 24 h than in controls at 1 mM P...

River bed sand and gravel are utilized more than mountain materials due to their availability and closeness to the transit roads and sites of usage. Excessive and non-technical extraction of gravel and sand bring a kind of interference in them, leading to many negative consequences. Therefore, presenting solutions to reduce these impacts and infilling mining pits are essential. In this researc...

Theoretical review of ‘mining pit lakes’ indicates that like natural lakes such lakes display a huge diversity. They are typically in a non-equilibrium state with respect to their surroundings. Hence, at the decommissioning phase of mining operation a detailed technical study are required on different aspects of such created water bodies considering its morphometry, geology, hydrology, water qu...

Pit Latrines and Groundwater Contamination Negative Impacts of a Popular Sanitation Method Worldwide an estimated 1.77 billion people use pit latrines as their primary mode of sanitation. With the prevalence of pit latrine use growing in developing countries, there is heightened concern about the negative impacts on drinking water. A new review assesses the known and measured environmental heal...

BACKGROUND Locoregional flaps are sufficient in most sacral reconstructions. However, large sacral defects due to malignancy necessitate a different reconstructive approach, with local flaps compromised by radiation and regional flaps inadequate for broad surface areas or substantial volume obliteration. In this report, we present our experience using free muscle transfer for volumetric reconst...

Objectives: Oral pentosan polysulfate (PPS) is the only FDA-approved drug for interstitial cystitis (IC). Several studies have been conducted that show PPS will reduce IC symptoms. Sacral neuromodulation is a newer therapy for IC that has been FDAapproved in incontinent patients. Studies conducted in IC patients have shown that sacral neuromodulation reduces IC symptoms. Both therapies have doc...

BACKGROUND Pelvic ring disruption when treated conservatively can be associated with prolonged hospital stay and immobilization, mal-union, chronic pain, limb length discrepancy if they are treated conservatively. Open reduction and fixation in an already compromised soft tissue and hemodynamically unstable patient causes more soft tissue injury, heamatoma, infection and neurovascular injury. P...

Noise produced by blast waves can be a problem, especially when an explosion occurs near populated areas. As one means of reducing the blast noise, the explosive is detonated in a pit, a space closed at the bottom and sides, open at the top. A two-dimentional finite difference model was used to simulate such an explosion in a pit and to determine to what extent the blast wave was attenuated. Th...