This study demonstrates that liposomes administered to the lower respiratory tract of mice have the capacity to stimulate secretory IgA (s-IgA) antibody production in the female urogenital system. Total respiratory tract immunization of mice with influenza virus subunit antigen simply mixed with negatively charged liposomes induced antigen-specific s-IgA in vaginal secretions, in addition to sy...

background : ascaridia galli , the largest nematode of small intestine of birds, especially the native poultry, may give rise to serious illness, pathological defects and economical losses even in modern poultry production systems. although various measures have been undertaken to vaccinate poultry against a.galli , no satisfactory results were obtained so far. however, there is no report on th...

background: to evaluate the immunological properties of leishmania major excreted- secreted (e-s) products on the progress of leishmaniasis in susceptible balb/c mice. methods: promastigotes of the leishmania major were cultured and e-s products were collected during the culture preiod. groups of balb/c mice (n= 12) were immunized with e-s products or whole antigen. animals were challenged with...

Tolerance to dsDNA is achieved through editing of Ig receptors that react with dsDNA. Nevertheless, some B cells with anti-dsDNA receptors escape editing and migrate to the spleen. Certain anti-dsDNA B cells that are recovered as hybridomas from the spleens of anti-dsDNA H chain transgenic mice also bind an additional, Golgi-associated antigen. B cells that bind this antigen accumulate intracel...

The Thomsen-Friedenreich (T) antigen is the core disaccharide of cancer-associated carbohydrates, whose expression allegedly correlates with the prognosis of some carcinomas. We studied the expression of the T antigen and its precursor (Tn) with monoclonal antibodies in formalin-fixed specimens of normal skin and various benign cutaneous tumours and inflammatory lesions (n: 105). In normal skin...

The seroreactivity of a cocktail of purified mycobacterial excretory–secretory (ES) antigens ES-31, ES-41 and ES43 was assessed by ELISA and immunoblotting in patients with pulmonary tuberculosis. The ES-31 antigen was isolated by affinity chromatography and ES-41 and ES-43 were isolated by fast protein liquid chromatography from Mycobacterium tuberculosis H37Ra culture filtrate. Seven of 27 pu...

in the present study, pancreas glands in mehraban breed of female sheep were histomorphometricallystudied in four different age groups included: fetus, newborn, sexually mature and old ages. the results ofhistomorphometrical analysis with regard to frequency and percentage of parenchymal and stromal structures such as, exocrine secretory units, secretory ducts, blood vessels, islets of langerha...

Eosinophils were discovered more than 140 years ago. These polymorphonuclear leukocytes have a very active metabolism and contain numerous intracellular secretory granules that enable multiple effects on both health disease status. Classically, eosinophils been considered important immune cells in the pathogenesis of inflammatory processes (eg, parasitic helminth infections) allergic or pulmona...

The canine heartworm, Dirofilaria immitis, is among the most important parasites of dogs in United States and worldwide, may cause severe potentially fatal disease. Current diagnostic recommendations rely on serological detection an adult female antigen, visualization microfilariae blood. Therefore, a reliable diagnosis can be only performed approximately six months post-infection. There growin...

oestrus ovis is an economically important parasite of small ruminants and a zoonotic parasite with many reports of ophthalmomyiasis in human from iran and other countries. the aim of the peresent studywas the isolation and identification of excretory-secretory (es) and somatic (s) antigens of o. ovis second and third stage larvae (l2, l3) collected from arabi sheep breeds located in southwest o...