Advanced Magnetic Resonance Imaging (MRI) techniques such as Diffusion Tensor Imaging (DTI) and resting-state functional MRI (rfMRI) are widely used to study structural and functional neural connectivity. However, as these techniques are highly sensitive to motion artifacts and require a considerable amount of time for image acquisition, successful acquisition of these images can be challenging...

INTRODUCTION Sedative and analgesic medications are routinely used in mechanically ventilated patients. The aim of this review is to discuss epidemiologic data that suggest a relationship between infection and sedation, to review available data for the potential causes and pathophysiology of this relationship, and to identify potential preventive measures. METHODS Data for this review were id...

OBJECTIVE While the use of a protocol to guide sedation and analgesia therapy in the intensive care unit has been shown to improve patient outcomes, compliance is often poor. We hypothesized that a formal, consistent intervention by pharmacists to promote adherence to our institution's sedation guidelines would improve clinical outcomes. The purpose of this study was to document the impact of d...

Objective: Fast-track and balanced anesthesia protocols have been developed in years, cardiac surgery. Conventional high-dose fentanyl midazolam techniques lost their popularity because of several known side effects. The primary aim this study is; to compare traditional terms postoperative pain sedation scales early extubation criterias. secondary is observe the effects these two different on i...

OBJECTIVE To describe the clinical characteristics of a combination of midazolam and ketamine for procedural sedation and analgesia in adult emergency department (ED) patients. METHODS This was a prospective, observational trial, conducted in the ED of an urban level II trauma center. Patients > or = 18 years of age requiring procedural sedation and analgesia were eligible, and enrolled patie...

OBJECTIVES To systematically review the literature comparing the efficacy and safety of dexmedetomidine and midazolam when used for procedural sedation. MATERIALS AND METHODS We searched MEDLINE, EMBASE and COCHRANE for clinical trials comparing dexmedetomidine and midazolam for procedural sedation up to June 20, 2016. Inclusion criteria: clinical trial, human subjects, adult subjects (≥18 ye...

a bstract background: mechanical ventilation is one of the supporting treatments that are used for different reasons. to reduce patients’ inconvenience caused due to using tracheal tube and ventilator, sedation is routinely used. using scales for the sedation, for example, richmond agitation sedation scale (rass), may reduce dose of sedation and length of mechanical ventilation.   materials and...

Question: Does early provision of rehabilitation improve the likelihood of functional independence at discharge in ventilated, critically ill patients? Design: Randomised, controlled trial with concealed allocation and blinded assessment of some outcomes. Setting: Two tertiary medical centres in the USA. Participants: Adults in a medical intensive care unit (ICU) who had been on mechanical vent...

Dexmedetomidine [Dex] is an α2-adrenoceptor agonist which provides sedation, analgesia and anxiolytic effects, thus making it a potentially useful anesthetic premedication. A number of clinical trials have been conducted to compare the sedative effect of Dex versus midazolam [Mdz], a conventional sedative agent in anesthesia. Nevertheless, consensus has not been achieved on which agent is super...