We identified and characterized 14 extragenic mutations that suppressed the dominant egg-laying defect of certain lin-12 gain-of-function mutations. These suppressors defined seven genes: sup-17, lag-2, sel-4, sel-5, sel-6, sel-7 and sel-8. Mutations in six of the genes are recessive suppressors, whereas the two mutations that define the seventh gene, lag-2, are semi-dominant suppressors. These...

The total phenol content, peroxidase and polyphenol oxidase enzyme activities and the total protein profile in tomato cultivars (Lycopersicon esculantum Mill.), tolerant and susceptible to Fusarium wilt disease was studied. The tolerant cultivars of tomato viz., FEB-2, FEB-4, FloraDade and NF-31 had significantly higher phenol content as well as peroxidase and polyphenol oxidase activities than...

This paper studies co-k-plex vertex partitions and more specifically co-2-plex vertex partitions. Co-k-plexes and k-plexes were first introduced in 1978 in the context of social network analysis. However, the study of co-k-plex vertex partitions, or the decomposition of graphs into degree bounded subgraphs, dates back at least to the work of Lovasz in 1966. In this paper, we derive analogues fo...

Plant viral movement proteins (MPs) enable viruses to pass through cell walls by increasing the size exclusion limit (SEL) of plasmodesmata (PD). Here, we report that the ability of Cucumber mosaic virus (CMV) MP to increase the SEL of the PD could be inhibited by treatment with the actin filament (F-actin)-stabilizing agent phalloidin but not by treatment with the F-actin-destabilizing agent l...

Plant viral movement proteins (MPs) enable viruses to pass through cell walls by increasing the size exclusion limit (SEL) of plasmodesmata (PD). Here, we report that the ability of Cucumber mosaic virus (CMV) MP to increase the SEL of the PD could be inhibited by treatment with the actin filament (F-actin)–stabilizing agent phalloidin but not by treatment with the F-actin–destabilizing agent l...

The detection of genetically modified (GM) maize events is an inevitable necessity under the strict regulatory systems many countries. To screen for GM events, we developed a multiplex PCR system to specifically detect 29 as well cauliflower mosaic virus 35S promoter, Agrobacterium tumefaciens nos terminator, Streptomyces viridochromogenes pat gene, and endogenous zSSIIb reference gene. These t...

Background Combination of selumetinib plus docetaxel provided clinical benefit in a previous phase II trial for patients with KRAS-mutant advanced non-small-cell lung cancer (NSCLC). The phase II SELECT-2 trial investigated safety and efficacy of selumetinib plus docetaxel for patients with advanced or metastatic NSCLC. Patients and methods Patients who had disease progression after first-lin...

Juvenile Chinook salmon, Oncorhynchus tshawytscha, were exposed to simulated high intensity pile driving signals to evaluate their ability to recover from barotrauma injuries. Fish were exposed to one of two cumulative sound exposure levels for 960 pile strikes (217 or 210 dB re 1 µPa(2)·s SEL(cum); single strike sound exposure levels of 187 or 180 dB re 1 µPa(2)⋅s SEL(ss) respectively). This w...

Ligands present on neighboring cells activate receptors of the LIN-12/Notch family by inducing a proteolytic cleavage event that releases the intracellular domain. Mutations that appear to eliminate sel-5 activity are able to suppress constitutive activity of lin-12(d) mutations that are point mutations in the extracellular domain of LIN-12, but cannot suppress lin-12(intra), the untethered int...