a simple, efficient, and high yielding one-pot protocol has been developed for the synthesis of 4h-benzo[b]pyrans scaffolds installing a three-component tandem knoevenagel-cyclocondensation reaction of an aldehyde, malononitrile and dimedone using guanidinium chloride as polyfunctional organocatalyst under solvent-free conditions in high to excellent yields. various aromatic aldehydes were util...

the aim of this study was to investigate the effect of computer games on intelligence quotient (iq), reaction time (rt), and movement time (mt) of adolescents. the statistical population of this study consisted of male high school students (aged between 14 and 18), restrict 1 in tabriz city. two samples (n1=n2=25) were selected purposefully and were divided into two equivalent groups (experimen...

Iso-butyric acid as a new, simple, and expensive solvent/catalyst was successfully used for the chemoselective Fischer’s synthesis of indolenines derivatives 3a-r by one-pot condensation reaction of various phenylhydrazines 1a-e with the substituted acetophenones 2a-c at reflux conditions. In this protocol, all products 3a-r were obtained in high yields and short reaction time. The structures o...

In this investigation, Nano silica chloride (nano SiO2Cl) has been found to be efficient, chemoselective and recyclable catalyst for facile and simple synthesis of germinal diacetates from aromatic and heteroaromatic aldehydes in shorter reaction durations. The products were obtained in high to excellent yields. This work consistently has the advantages of excellent yields, short reaction time,...

Many biochemical reaction networks are inherently multiscale in time and in the counts of participating molecular species. A standard technique to treat different time scales in the stochastic kinetics framework is averaging or quasi-steady-state analysis: it is assumed that the fast dynamics reaches its equilibrium (stationary) distribution on a time scale where the slowly varying molecular co...

results our study showed that the sensitivity and specificity of taqman real time pcr was 96% and 95% respectively. these values were 89% and 90, 38% and 100%, 6% and 100% for pcr, culture and microscopy, respectively. conclusions our study showed that sensitivity of taqman real time pcr was higher that pcr, culture and microscopy but specificity of culture and microscopy was more than pcr and ...

Brucellosis is primarily a worldwide zoonotic disease caused by Brucella species. The genus Brucella contains highly infectious species that are classified as biological threat agents. In this regard, the identification of Brucella can be a time-consuming and labor-intensive process posing a real risk of laboratory-acquired infection to the laboratory staff. This stud...

Sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) with a pore size of 6 nm catalyzed three component coupling of aromatic aldehydes, urea and ethyl acetoacetate to afford the corresponding dihydropyrimidinones under solvent free condition. This new protocol for Biginelli reaction has important advantages such as green synthesis, short reaction time, easy isolation and high yields of ...

In this research, a green, operationally simple, highly efficient and facile cascade Biginelli reaction using various aromatic aldehydes, ethyl acetoacetate, and urea/thiourea has been developed. First, the ionic liquid was prepared from the reaction of 1-methyl-2-pyrolidone with methane sulfonic acid. Then, this ionic liquid was applied as an acidic catalyst in the synthesis of dihydropyrimidi...

A simple, green and efficient method for synthesis of 2,4,5-trisubstituted imidazoles is described via three-component cyclocondensation of benzil or benzoin, aldehyde and ammonium acetate by using the nano SiO2-supported ferric hydrogen sulfate (FHS/SiO2), as a catalyst, under solvent-free conditions. The nano SiO2 support and catalyst were characterized by X-ray diffraction (XRD), transmissio...