TO THE EDITOR Hair loss or hair color change in patients taking valproate has been repeatedly reported. However, drug-induced hair texture changes have been reported rarely. Curly hair is a very rare side effect of valproate. Valproate is recommended for the acute treatment of mania and maintenance of bipolar disorder as a mood stabilizer. Valproate can be used also in the treatment of epilepsy...

A case of severe sodium valproate overdose is presented in which continuous venovenous haemodiafiltration was used. However, following the commencement of dialysis and a fall in the serum valproate levels, the patient developed cerebral oedema. This case demonstrated a poor correlation between serum valproate and its toxic effects and the lack of benefit of continuous venovenous haemodiafiltrat...

A double-blind crossover study of sodium valproate and placebo was conducted in five patients with Meige syndrome. CSF neurotransmitter studies were performed at the end of each treatment period. GABA levels were not influenced by the administration of sodium valproate. An increase in HVA levels was observed in every patient, which may reflect an increase in central dopaminergic activity. This ...

Epilepsy is one of the common neurologic disorders in children. Drug side-effects are one of the important problems in treating patients with epilepsy. Using the antiepileptic medication may cause different side effects such as disorder in bone and vitamin D metabolism. Sodium valproate is one of the antiepileptic medications used widely. Some of its side effects include digestive disorder, inc...

To the Editor: pliance with therapy. Annual rates of vaso-occlusive crisis were calculated as previously described by dividing the number of crises by the number of years of therapy (for example, 2 crises Increased synthesis of fetal hemoglobin may ameliorate the cliniin 6 months Å 4 crises per year). The number of days spent in cal severity of sickle cell disease; both chemotherapeutic and non...

To the Editor: pliance with therapy. Annual rates of vaso-occlusive crisis were calculated as previously described by dividing the number of crises by the number of years of therapy (for example, 2 crises Increased synthesis of fetal hemoglobin may ameliorate the cliniin 6 months Å 4 crises per year). The number of days spent in cal severity of sickle cell disease; both chemotherapeutic and non...

abstract: warfarin is the most commonly used oral anticoagulant drug in clinical practice with extreme inter and intra-individual variation in pharmacokinetic properties. na valproate, a broad spectrum anticonvulsant agent, is best known for its enzyme inhibition properties and also displacement of protein binding sites. interaction between warfarin and psychotropic drugs including valproate ar...

Targeting epigenetic changes in diffuse intrinsic pontine glioma (DIPG) may provide a novel treatment option for patients. This report demonstrates that sodium valproate, a histone deacetylase inhibitor (HDACi), can increase the cytotoxicity of carboplatin in an additive and synergistic manner in DIPG cells in vitro. Sodium valproate causes a dose-dependent decrease in DIPG cell viability in th...