Paraquat (PQ), is one of the most widely used herbicides all over the world. PQ could induce dopaminergic cell death. Since dopamine involves in memory processing, we investigated the recovery effect of vitamin C on spatial memory along with oxidative stress parameters during PQ induced neurotoxicity in male rats. Rats were divided into five groups (n= 7): control (saline 0.9%), PQ (2.67 and 5 ...

objective: this study was designed to examine the effect of environmental enrichment during methamphetamine (meth) dependency and withdrawal on methamphetamine-induced spatial learning and memory deficits and obsessive-compulsive behavior. method: adult male wistar rats (200 ± 10 g) chronically received bi-daily doses of meth (2 mg/kg, sc, with 12 hours intervals) for 14 days. rats reared in st...

lead (pb2+) is a well known neurotoxin that was frequently found in the environment and chronic exposure to lead has been matter of public health. in the present study the effect of lead on spatial memory in developmentally exposed rats and their dams in morris water maze task were investigated. female rats were divided into three groups and two groups exposed to 250 and 750 part per million (p...

Previous studies have shown that ascorbic acid (AA) plays a crucial role in mammalian brain as avitamin and neuronal modulator. There is increasing evidence indicating that dopaminergic system and AAcould affect learning and memory processes. In addition, vitamin C acts as a dopamine antagonist in thebrain. The aim of the present study was to evaluate the intra-hippocampal co-administration of ...

Introduction: Cognitive dysfunction is the most common problem of patients with Alzheimer disease (AD). The pathological mechanism of cognitive impairment in AD may contribute to neuronal loss, synaptic dysfunction, and alteration in neurotransmitters receptors. Mitochondrial synapses dysfunction due to the accumulation of amyloid beta (Aβ) is one of the earliest pathological features of AD. Th...

Androgens have been shown to affect cognitive aspects of spatial memory. Testosterone which is the most important androgen, plays a role in the organization of behavior during development. Also, it has been shown that androgens cause sex related differences in learning and memory especially during neonatal period. In the current study, we assessed the effects of castration and testosterone ena...

the aim of this study was to investigate the effect of inflammatory pulpal pain on spatial learning and memory in male wistar rats. fifty-six adult rats were divided into eight groups as follows (n=7 per group): control, sham-operated group that received normal saline, sham vehicle group that received vehicle of capsaicin, three capsaicin treated groups that received intradental injection of 10...