PURPOSE The Krüppel-like transcription factor KLF4/GKLF induces both malignant transformation and a slow-growth phenotype in vitro. Although KLF4 expression is increased in most cases of breast cancer, it was unknown whether these cases represent a distinct subtype with a different clinical outcome. EXPERIMENTAL DESIGN We examined expression of KLF4 by immunostaining 146 cases of human primar...

background: alteration in peripheral blood lymphocytes (pbls) is usually investigated to provide an evidence of the host immune responses to tumor antigens. the tumor infiltrating nk cells interact most closely with the tumor cells and more accurately reflect tumor host interactions. objective: to analyze peripheral blood and tumor associated natural killer (nk) cells in patients with breast ca...

BACKGROUND Breast carcinoma remains the most prevalent cancer among women, with over 300 000 deaths annually worldwide. Axillary lymph node status is essential for the clinical staging of breast carcinoma and remains the single most important predictor of disease-free survival in breast carcinoma. OBJECTIVE To determine effective histological examination of sentinel lymph node (SLN) sections ...

Emerging evidence has revealed that promyelocytic leukemia zinc finger may contribute in several ways to the development and progression of cancer, but no pan-cancer analysis its roles have been undertaken date. Here, we set out use bioinformatics techniques comprehensively investigate expression profiles prognostic significance finger, as well relationship clinic pathological parameters immune...

The 82nd general meeting of the Association of Clinical Pathologists was held in Harrogate on 17, 18, and 19 April 1969. The programme included a symposium on 'The small intestine' at which invited speakers read the papers. This symposium will be published in the Journal later in the year. The second symposium was concerned with 'Radioisotopes in the pathology laboratory'. There was also a foru...

NK cells are a major component of the antitumour immune response that limits tumour progression. However, it has been reported that tumour-infiltrating NK (TINK) cells from patients with non-small-cell lung carcinoma (NSCLC) exhibit profound defects in degranulation and IFN-γ production. In support of this notion, we report a novel mechanism associated with tumour escape from NK cell-mediated a...

Hepatocellular carcinoma (HCC) is frequently associated with infiltrating mononuclear inflammatory cells. We performed laser capture microdissection of HCC-infiltrating and noncancerous liver-infiltrating mononuclear inflammatory cells in patients with chronic hepatitis C (CH-C) and examined gene expression profiles. HCC-infiltrating mononuclear inflammatory cells had an expression profile dist...

right breast (53%) while about 43% had of left breast. Patients with breast cancer were mostly married (99%) & patients were belonging to poor socioeconomic status. Diagnostic tests performed for most of the cancer patients were mammography, biopsy, USG, X-ray & MUGA & bone scan and about 60% of the population had undergone mastectomy. CONCLUSIONS: Infiltrating ductal carcinoma (96%) was found ...

OBJECTIVE To describe cases of breast cancer in women living in Goiânia from 1989-2003. METHODS We conducted a retrospective, descriptive stud, which included all cases of breast cancer occurring in residents of Goiânia, identified by the Population-Based Cancer Registry of Goiânia (RCBPGO) in the period from 1989 to 2003. The variables were: age, method of diagnosis, topographic location, mo...