Pain is a frequent presenting symptom of spinal cord tumors in children and usually manifests as local spinal pain in the bony segments overlying the tumor. Two pediatric patients are presented in whom the diagnosis of intramedullary spinal cord tumors was delayed for many months because their pain was atypical. One had recurrent abdominal pain diagnosed as irritable bowel syndrome. The other h...

This article has been subjected to double blind peer review The first two articles in this series described the anatomy and physiology of the vertebral column and spinal cord, and examined the aetiology and pathophysiology of spinal cord injuries (Sheerin 2004, 2005). These provide a basis for understanding the presentation and management of spinal cord injuries. It is difficult to be prescript...

Recently, evidence has been raised that long-term changes in the central nervous system are mediated by extrasynaptic spread of neuropeptides (‘volume transmission’). To study the effects of volume transmission in the spinal cord we developed the technique of controlled superfusion of the rat cord dorsum. This paper presents quantitative data about the spread, local spinal tissue concentration ...

The case report titled “Acute renal failure during a trial of spinal cord stimulation: Theories as to a possible connection” by Larkin et al (1) addressed that spinal T9 stimulation could lead to diminished renal blood flow by the decreased sympathetic input. Renal sympathetic innervation is widely acknowledged to involve the maintenance of fluid homeostasis and modulation of renal hemodynamics...

background and objective: evaluation of degenerative changes of motoneurons and their related synapses can be useful in understanding the mechanisms of neurodegenerative diseases and their potential treatment. the present electron microscopic and immunohistochemical study investigates the axotomy-induced changes of adult spinal motoneurons up to 3 months following sciatic nerve transection. mat...

Objective(s): AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models. The aim of this study was to evaluate the effect of AMPK/SIRT1 pathway on autophagy after spinal cord injury (SCI). Materials and Methods:The SCI model was established in rats in vivo and the primary spinal cord neurons were subject...

Spinal cord injury (SCI) is damage to the spinal cord that leads to sudden loss of motor and autonomic function and sensory under the level of the injury. Studies showed that individuals with SCI has a clear tendency to vitamins level change. The aim of this study was to review the vitamins level in spinal cord injury. Vitamins C level decrease in the injured spinal cord patient. Vitamins C hav...

initial presentation of diastematomyelia is rarely seen in adults. the purpose of this case report is to present a case of clinically silent diastematomyelia unrecognized into adulthood and review of the literature. a 53-year-old persian man was admitted to our hospital with gait disturbance, weakness of the right lower extremity, sensory loss of the left and right lower extremity of two weeks’...

Spinal cord injuries alter motor function by disconnecting neural circuits above and below the lesion, rendering sensory inputs a primary source of direct external drive to neuronal networks caudal to the injury. Here, we studied mice lacking functional muscle spindle feedback to determine the role of this sensory channel in gait control and locomotor recovery after spinal cord injury. High-res...