Background: Preimplantation genetic diagnosis - PGD is currently an established procedure allowing genetic research of oocyte or embryo before implantation to the uterus. Spinal muscular atrophy (SMA) is a neurodegenerative disorder, being the second most common lethal autosomal recessive disease in Caucasians, after cystic fibrosis. There are three clinically different types of which type I (W...

Diffuse idiopathic skeletal hyperostosis (DISH) and ankylosing spondylitis (AS) share involvement of the axial skeleton and peripheral entheses. Both diseases produce bone proliferations in the later phases of their course. Although the aspect of these bone proliferations is dissimilar, confusion of radiologic differential diagnosis between the two diseases exists mostly as a consequence of a l...

Stem cells have been recognized and intensively studied for their potential use in restorative approaches for degenerative diseases and traumatic injuries. In the central nervous system (CNS), stem cell-based strategies have been proposed to replace lost neurons in degenerative diseases such as Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (Lou Gehrig's disease), ...

Earlier studies have revealed that the more the preference to schedule daily activities towards the evening hours is, the higher the odds for a range of health hazards are. Therefore, we wanted to analyze, whether the behavioral trait of morningness-eveningness is associated with articular and spinal diseases or those with musculoskeletal disorders. Participants (n = 6089), as part of the Natio...

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the degeneration of upper motor neurons in brainstem and spinal cord lower neurons. ALS was first described Jean-Martin Charcot 1874 based on clinical features postmortem examinations. In 1990, diagnostic criteria for were developed features. Subsequently, three additional published. this article, we...

The retrospective study was designed to compare the diagnostic value of computed radiography, magnetic resonance imaging, computed tomography, and electrodiagnostic procedures like brainstem evoked potentials and somatosensory evoked potentials in cervical spinal cord diseases in dogs; including wobbler syndrome, intervertebral disc disease, trauma, neoplasma, and syringomelia. Thirty-one dogs ...

A mandated by the Italian Ministry of Health, the Italian Society of Physical Medicine and Rehabilitation (Società Italiana Medicina Fisica e Riabilitazione, SIMFER) appointed a Commission composed of SIMFER members to draw up guidelines for the rehabilitation treatment of adolescents with spinal deformities. Other medical organizations contributing to the redaction of the final guidelines vers...

BACKGROUND The indications and timing of treatment, as well as the best treatment method for traumatic central cord syndrome (CCS), remain controversial. The aims of this study are to determine the prognostic factors of traumatic CCS and to determine appropriate surgical indications. METHODS We reviewed the clinical and radiological data of 47 patients with this syndrome. The data collected i...

Background: The link between body weight status and spinal diseases has been suggested by a number of cross-sectional and cohort studies with a limited range of patient populations. No population-representative samples have been used to examine the link between obesity and spinal diseases. The present study is based on a nationally representative sample drawn from the Medical Expenditure Panel ...