نتایج جستجو برای: sporadic prostate cancer
تعداد نتایج: 951267 فیلتر نتایج به سال:
Background:Prostate cancer is increasing among Iranian men and gene polymorphisms may play a role in the development of prostate cancer. Insulin-like growth factor 1 (IGF1) gene polymorphisms have been deeply explored in different malignancies. In this study, we aimed to explore the association of IGF1 CA repeat length polymorphism with the risk of prostate cancer development i...
Background: The clinical pathological features were detected by measuring the prostatic acid phosphatase (PAP) activity according to the stages and grades of prostate cancer. We also explored the relationship between the disease and age with family history among the patients. Methods: Data were collected from direct interview and from the patient’s records. Blood samples that collected before ...
Background: Prostate cancer is one of the most common diseases that affect men. Although prostate cancer is not the fatal flaw in most cases, detection of effective factors for early diagnosis and treatment is essential. Research results have shown that the use of KLK2 plus PSA can be a good biomarker for diagnosing prostate cancer. During prostate cancer, expression of KLK2 gene increases whic...
Background: Impaired DNA repair mechanism is one of the main causes of tumor genesis. Study of intrinsic radiosensitivity of cancer patients in a non-target tissue (e.g. peripheral blood) might show the extent of DNA repair deficiency of cells in affected individuals and might be used a predictor of cancer predisposition. Methods: Initial radiation-induced DNA damage (ratio of Tail DNA/Head DN...
results a total number of 43 specimens were studied, from which 9 were obtained from patients with metastatic prostate cancer. the expression of five examined genes had no correlation with psa level and gleason score. the expression of amacr decreased in metastatic prostate cancer (p = 0.02). the expression of other genes showed no difference between metastatic and non-metastatic tumors (p > 0....
background: prostate cancer is one of the most widespread cancers in men and is fundamentally a genetic disease. identifying regulators in cancer using novel systems biology approaches will potentially lead to new insight into this disease. it was sought to address this by inferring gene regulatory networks (grns). moreover, dynamical analysis of grns can explain how regulators change among dif...
ionization radiation caused to incidence of complications in the exposed organs. in prostate radiotherapy, rectum and bladder have been radiated unwantedly and indicated some complications during and after treatment. the purpose of present study is to consider and to compare clinical complications of rectum and bladder in custom block and mlc for 3- d conformal radiotherapy, in order to determi...
background: to correct patient positioning errors (setup errors) during prostate cancer treatment using epid and fiducial gold markers, to improve the accuracy of the dose delivery in these patients. materials and methods: fifteen patients with localized prostate carcinoma after implantation of fiducial gold markers in their prostate gland underwent the five-field imrt planning technique. the p...
background and aims: prostate cancer is the second most common cancer in men worldwide in men. matrix metalloproteinase 2 (mmp2) has a role in the invasion and destruction of the basement membrane and the extra-cellular matrix and facilitating the process of tumor cell invasion. the present study was conducted to compare the expression of mmp2 gene in prostate cancer (pca) and benign prostatic ...
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