the interactions between platinum complexes and human serum albumin (hsa) play crucial roles in the distribution, metabolism, and activity of platinum-based anticancer drugs. octahedral platinum (iv) complexes represent a significant class of anticancer agents that display molecular pharmacological properties different from cisplatin. in this study, the interaction between two pt(iv) complexes ...

indium is a heavy metal belonging to group iiia. it is used as a radioimaging and chemotherapeutic agent in diagnosis and also in the treatment of cancers. it is believed that indium may interfere with iron metabolism and reduce cell growth in cancer tissue. the present report was established to study the binding of iron and indium to apo-transferrin (apo-tf) and to identify amino acids involve...

Domperidone is a widely used antiemetic, poorly water soluble drug, erratically absorbed in stomach and possess several dissolution-related problems thus it has poor bioavailability. Solubility of a drug plays a very important role in dissolution and hence absorption of drug which ultimately affects its bioavailability. Hence, by considering the facts related to drug, attempts have been made to...

Domperidone is a widely used antiemetic, poorly water soluble drug, erratically absorbed in stomach and possess several dissolution-related problems thus it has poor bioavailability. Solubility of a drug plays a very important role in dissolution and hence absorption of drug which ultimately affects its bioavailability. Hence, by considering the facts related to drug, attempts have been made to...

curcumin (cur) is the active curcuminoid with many physiological, biochemical, and pharmacological properties. solubility and stability of cur is the limiting factors for realizing its therapeutic potential. bovine β-casein is an abundant milk protein that is highly amphiphilic and self-assembles into stable micellar nanoparticles in aqueous solution. β-casein nanoparticle can solubilize cur mo...

The polarographic study of Cd(II) with L-Tyrosine has been investigated in aqueous organic solvent mixtures at 300K. The Dimethyl sulphoxide and Dimethyl formamide solvents have been used with water to study the effect of solvents on the stability of complexes. Cadmium(II) formed 1:1, 1:2 and 1:3 complexes with L-Tyrosine in the aqueous-organic solvent mixture i.e. DMSO and DMF. The stability c...

A new tetradentate N2O2 Schiff base ligand (MeO-bph)2bn = N,N¢-bis(2-hydroxy-4-methoxybenzophenone)-1,4-butanediamine was prepared from the condensation of butane-1,4-diamine with 4-methoxy-2-hydroxybenzophenone and characterized by 1H-NMR spectroscopy and single-crystal X-ray diffraction. Its nickel(II) and copper(II) complexes characterized usin...

Linear–dendrite copolymers containing hyper branched poly(citric acid) and linear poly(ethylene glycol) blocks PCA–PEG–PCA are promising nonmaterial to use  in nanomedicine. To investigate their potential application in biological systems (especially for drug carries) ONIOM2 calculations were applied to study the nature of particular interactions between drug and the polymeric nanoparticle...