Systemic fungal infections are a major cause of morbidity and mortality in neutropenic patients. Approximately 25% of patients with leukemia have evidence of fungal infection at autopsy. The incidence of fungal infection is increasing in immunosuppressed patients especially in the hcmato-oncology patients. This is probably due to several factors including prolonged period of neutropenia, the us...

Several five membered ring systems, e.g., triazole, oxadiazole dithiazole and thiadiazole with three heteroatoms at symmetrical or asymmetrical positions have been studied because of their interesting pharmacological properties. In this article our emphasis is on synthetic development and pharmacological activity of the triazole moiety which exhibit a broad spectrum of pharmacological activity ...

luconazole (Diflucan(R), Roerig, New York, NY) was recently developed for the treatment of systemic and surface fungal infections. It is an azole in the same family as ketoconazole and itraconazole. Fluconazole has several advantages over the other antifungal drugs including the option of oral therapy. The side-effect profile is minimal. Studies have shown it to be efficacious for the treament ...

Optimal management of fungemia in neutropenic patients is still controversial. Several reports have already stressed the poor prognosis in invasive candidiasis (80% mortality in several reports). Therefore granulocyte transfusions would appear to be useful in the management of these infections. We report the use of rhG-CSF-primed granulocyte transfusions plus amphotericin B in two neutropenic p...

Skin fungal infections are common global problems with attendant morbidity amongaffected individuals. Children are mostly affected because of predisposing factors such aspoverty, overcrowding, and lack of guidance. Investigation on the prevalence ofsuperficial fungal infections among primary school pupils was carried out in Awka SouthLocal Government Area of Anambra State, Nigeria. Six public p...

background and purpose: use of curcumin, as a promising antifungal agent, is considered an alternative treatment for fungal infections; however, the low solubility of this agent limits its efficacy. accordingly, in this study, we aimed to evaluate the in vitro and in vivo antifungal activities of dendrosomal nanocurcumin with improved solubility and bioavailability. materials & methods: the in ...

A major group of drugs that have been approved for the therapy of systemic fungal infections are polyene antibiotics. Amphotericin B (AmB), one of the polyene antibiotics, has been used to treat serious systemic fungal infections by binding to sterols such as ergosterol in fungal cells membrane, and is believed to form pores in the membrane and create a transmembrane ion-channel. Since all euka...

Hospitalized patients have a potential risk for nosocomial infections. Airborne fungi are one of the main causes of fungal infections in this group. The objective of this study was to investigate the concentrations and species of airborne fungi in two general hospitals in Shiraz, southern Iran. Air samples were collected from high-risk wards, using settle plate method. Fungal colonies were iden...

We recently demonstrated that macrophage migration inhibitory factor deficient (MIF (- / -)) mice exhibited a higher susceptibility to lethal systemic Aspergillus fumigatus infections than genetically matched, wild-type (WT) C57BL/6 mice, and displayed altered cytokine profiles in the spleen when challenged by sublethal infections. In this report we focused on the potential involvement of MIF i...

background and purpose: soil is the main habitat of saprophytic and pathogenic fungi. mucormycetes are one of the most parts of soil fungi and certain members are among opportunistic fungi and can cause systemic fungal infections in immunocompromised patients. the majority of human and animal infections are caused by members of the genera rhizopus, mucor, rhizomucor, lichtheimia (absidia), cunn...