Direct tableting is simpler and more cost-effective from the point of view of good manufacturing practice (GMP) than wet granulation or dry compacting. Moreover, the use of dry plant extracts in the process of direct tableting, omitting granulation, decreases the possibility of biological activity loss of active substances. Thus, pharmaceutical industry uses this particular process more and mor...

Abstract A series of microemulsions based on oleic acid and Tween 80, modified with piperidinium surfactants, have been obtained characterized. The effect additives the size, stability, solubilization formed systems respect to hydrophilic (rhodamine B) hydrophobic (indomethacin) substances investigated. Varying components ratio has allowed preparation strongly different viscosity: from easy-flo...

Pharmaceuticals are biologically active and persistent substances which have been recognized as a continuing threat to environmental stability. Chronic ecotoxicity data as well as information on the current distribution levels in different environmental compartments continue to be sparse and are focused on those therapeutic classes that are more frequently prescribed and consumed. Nevertheless,...

Last month, Part 1 of this discussion brief ly described the regulatory landscape for developing biosimilar therapeutic monoclonal antibodies (TMAbs). We identified certain specific structural components of TMAb drug substances that warrant particular attention because alterations to them are likely to affect therapeutic safety and effectiveness. Now we conclude by considering whether studies o...

The type 2 immune response is an adaptive immune program involved in defense against parasites, detoxification, and wound healing, but is predominantly known for its pathophysiological effects, manifesting as allergic disease. Engineered nanoparticles (NPs) are non-self entities that, to our knowledge, do not stimulate detrimental type 2 responses directly, but have the potential to modulate on...

From the ancient method of bloodletting until the recent possibilities by immunoadsorption, the removal of pathologic substances from blood is one of the oldest therapeutic approaches in medicine. The list of indications for this procedure has always been abundant and its scientific background remains a matter of discussion. On December 8, 1914, John Abel performed the first therapeutic apheres...

in this study, the effect of some toxic organic chemicals on mogan lake has been investigatedusing the aquatox model. the unique property of the model includes the sub ecotoxicological modelwhen compared to the other water quality models. the ecosystem model aquatox, which is one of the fewgeneral ecological risk models that represents the combined environmental repercussions and effects of tox...

during the past few years, there has been an increasing recognition that internet is playing a significant role in the synthesis, the distribution and the consumption of novel psychoactive substances (nps).the aim of this study was to assess the online availability of nps in persian language websites.the google search engine was used to carry out an accurate qualitative assessment of informatio...

nowadays nanotechnology as a new direction of science allows us to develop therapeutic methods of the endogenous intoxication syndrome and to create a new class of biocompatible sorbents. in ukraine first preparations of medical nanotechnology were produced and patented in 1998. these are ikbb (intracorporeal biocorrector), magnet-controlled sorbent (mcs-b), and micromage-b. the preparations ar...