Intraarterial chemotherapy with Adriamycin (ADM) has shown limited advantages over i.v. administration, with no reduction in systemic toxicities and modest decrease in peripheral plasma levels. In an effort to improve the selectivity of i.a. anthracycline chemotherapy, we compared pirarubicin (4'-O-tetrahydropyranyladriamycin, THP) and ADM in the surgically implanted VX2 rabbit tumor model. Bot...

The Two-hop problem (THP) (also known as the minimum forwarding set problem) is to select a minimum set of one-hop neighbors of a given source node to broadcast messages to all of its two-hop neighbors. Despite the simplicity of THP, its computation complexity is unknown. Consider a bipartite graph B(A,B, E) such that the degree of any node in A is 3 and degree of any node in B is 2. If B can b...

Tamm-Horsfall glycoprotein (THP) from healthy probands inhibits the precipitation of calcium oxalate, whereas THP from individuals who repeatedly develop calcium oxalate stones has no effect or even promotes precipitation. Using Fourier-transform infrared spectroscopy, we found a structural differentiation between these functionally different THPs: a decisive difference in sialic acid content. ...

Background: Macrophage immune responses are affected by the secretory proteins of Mycobacterium tuberculosis (Mtb). This study aimed to examine the immune responses of macrophages to Mtb secretory antigens, namely ESAT-6, CFP-10, and ESAT-6/CFP-10.Methods: THP-1 cells (a human monocytic cell line) were cultured and differentiated to macrophages by phorbol 12-myristate 13-acetate. The cytotoxici...

Pathogens infecting mammalian cells have developed various strategies to suppress and evade their hosts’ defensive mechanisms. In this line, the intracellular bacteria that are able to survive and propagate within their host cells must have developed strategies to avert their host’s killing attitude. Studying the interface of host-pathogen confrontation can provide valuable information for defi...

A convergent one-step transformation of tetrahydropyranyl (THP) ethers is described. According to our earlier experiments, indium(III) triflate has proven to be an efficient catalyst for the transformation of THP ethers into their corresponding acetates. In further intensive work, we have developed a useful transforming reaction of THP ethers using various anhydride moieties. Indium(III) trifla...

Flavonoids are known to exert anti-inflammatory activity but their mechanism at receptor level and comparative potencies less studied. Objective of the study is evaluate, rank order few flavonoids for cytokine inhibitory in monocytes (THP-1) explore signature among toll-like receptors (TLRs). We tested potential inhibit LPS induced cytokines IL-6, TNF alpha human monocyte cell line THP-1 mouse ...

pathogens infecting mammalian cells have developed various strategies to suppress and evade their hosts’ defensive mechanisms. in this line, the intracellular bacteria that are able to survive and propagate within their host cells must have developed strategies to avert their host’s killing attitude. studying the interface of host-pathogen confrontation can provide valuable information for defi...

background: recently different studies suggested that discontinuation of gonadotrophin releasing hormone analogue (gnrha) at beginning of ovarian stimulation (improvement of ovarian response to gonadotrophins) may have some benefit to poor responder patients in invitro fertilization (ivf) cycles. objective:the efficacy of gnrha stop protocol in poor responder patients in ivf cycles was assessed...

objective: this study was conducted to compare the results of fixed versus flexible gnrh antagonist protocols in controlled ovarian stimulation for intra cytoplasmic sperm injection (icsi) in patients with pcos. materials and methods: a randomized clinical trial was performed on 100 pcos women, who were admitted to a tertiary infertility clinic and were candidate for ivf/icsi. they were divided...